[HTML][HTML] IP-10 is highly involved in HIV infection

J Lei, X Yin, H Shang, Y Jiang - Cytokine, 2019 - Elsevier
Abstract Interferon-γ (IFN-γ)-induced protein 10 (IP-10 or CXCL-10) is a chemokine involved
in trafficking immune cells to inflammatory sites. Numerous studies have reported …

Cellular and molecular insights into incomplete immune recovery in HIV/AIDS patients

L Yan, K Xu, Q Xiao, L Tuo, T Luo, S Wang… - Frontiers in …, 2023 - frontiersin.org
Highly active antiretroviral therapy (ART) can effectively inhibit virus replication and restore
immune function in most people living with human immunodeficiency virus (HIV). However …

High Abundance of genus Prevotella in the gut of perinatally HIV-infected children is associated with IP-10 levels despite therapy

US Kaur, A Shet, N Rajnala, BP Gopalan, P Moar… - Scientific reports, 2018 - nature.com
Perinatal HIV infection is characterized by faster HIV disease progression and higher initial
rate of HIV replication compared to adults. While antiretroviral therapy (ART) has greatly …

IP-10 Promotes Latent HIV Infection in Resting Memory CD4+ T Cells via LIMK-Cofilin Pathway

Z Wang, X Yin, M Ma, H Ge, B Lang, H Sun… - Frontiers in …, 2021 - frontiersin.org
A major barrier to HIV eradication is the persistence of viral reservoirs. Resting CD4+ T cells
are thought to be one of the major viral reservoirs, However, the underlying mechanism …

Transcriptomics and targeted proteomics analysis to gain insights into the immune-control mechanisms of HIV-1 infected elite controllers

W Zhang, AT Ambikan, M Sperk, R van Domselaar… - …, 2018 - thelancet.com
A small subset of HIV-1 infected individuals, the" Elite Controllers"(EC), can control viral
replication and restrain progression to immunodeficiency without antiretroviral therapy …

Distinct type I interferon subtypes differentially stimulate T cell responses in HIV-1-Infected individuals

Z Karakoese, M Schwerdtfeger, CB Karsten… - Frontiers in …, 2022 - frontiersin.org
The expression of type I interferons (IFNs) is one of the immediate host responses during
most viral infections. The type I IFN family consists of numerous highly conserved IFNα …

Impact of plasma IP-10/CXCL10 and RANTES/CCL5 levels on neurocognitive function in HIV treatment-naive patients

V Ruhanya, GB Jacobs, S Naidoo, RH Paul… - AIDS research and …, 2021 - liebertpub.com
Immune activation, which is accompanied by the production of proinflammatory cytokines, is
a strong predictor of disease progression in HIV infection. Inflammation is critical in neuronal …

Social isolation is linked to inflammation in aging people with HIV and uninfected individuals

RJ Ellis, J Iudicello, N Sun-Suslow… - JAIDS Journal of …, 2021 - journals.lww.com
Background: Even in the era of suppressive antiretroviral therapy, people with HIV (PWH)
suffer greater exposure to inflammation than their uninfected peers. Although poor social …

Cytokines, chemokines and growth factors profile in human aqueous humor in idiopathic uveitis

MH Errera, A Pratas, S Fisson, T Manicom… - PLoS …, 2022 - journals.plos.org
To investigate which cytokines, chemokines and growth factors are involved in the
immunopathogenesis of idiopathic uveitis, and whether cytokine profiles are associated …

Biomarkers of activation and inflammation to track disparity in chronological and physiological age of people living with HIV on combination antiretroviral therapy

M Thurman, S Johnson, A Acharya… - Frontiers in …, 2020 - frontiersin.org
With advancement, prompt use, and increasing accessibility of antiretroviral therapy, people
with HIV are living longer and have comparable lifespans to those negative for HIV …