Strategies based on organ decellularization and recellularization

KH Hillebrandt, H Everwien, N Haep… - Transplant …, 2019 - Wiley Online Library
Transplantation is the only curative treatment option available for patients suffering from end‐
stage organ failure, improving their quality of life and long‐term survival. However, because …

Lung endothelium, tau, and amyloids in health and disease

R Balczon, MT Lin, S Voth, AR Nelson… - Physiological …, 2024 - journals.physiology.org
Lung endothelia in the arteries, capillaries, and veins are heterogeneous in structure and
function. Lung capillaries in particular represent a unique vascular niche, with a thin yet …

Angiogenesis and re-endothelialization in decellularized scaffolds: recent advances and current challenges in tissue engineering

R Mazloomnejad, A Babajani, M Kasravi… - … in Bioengineering and …, 2023 - frontiersin.org
Decellularization of tissues and organs has recently become a promising approach in tissue
engineering and regenerative medicine to circumvent the challenges of organ donation and …

Human-scale lung regeneration based on decellularized matrix scaffolds as a biologic platform

K Ohata, HC Ott - Surgery today, 2020 - Springer
Lung transplantation is currently the only curative treatment for patients with end-stage lung
disease; however, donor organ shortage and the need for intense immunosuppression limit …

Lung microvascular niche, repair, and engineering

T Tsuchiya, R Doi, T Obata, G Hatachi… - … in Bioengineering and …, 2020 - frontiersin.org
Biomaterials have been used for a long time in the field of medicine. Since the success of
“tissue engineering” pioneered by Langer and Vacanti in 1993, tissue engineering studies …

Bioengineering and clinical translation of human lung and its components

ID Derman, YP Singh, S Saini, M Nagamine… - Advanced …, 2023 - Wiley Online Library
Clinical lung transplantation has rapidly established itself as the gold standard of treatment
for end‐stage lung diseases in a restricted group of patients since the first successful lung …

Lung bioengineering: advances and challenges in lung decellularization and recellularization

JJ Uriarte, FE Uhl, SER Enes, RA Pouliot… - Current opinion in …, 2018 - journals.lww.com
Bioengineering the lung using recellularized scaffolds could offer a curative option for
patients with end-stage organ failure but its accomplishment remains unclear in the short …

Bioactive cell-derived ECM scaffold forms a unique cellular microenvironment for lung tissue engineering

A Doryab, O Schmid - Biomedicines, 2022 - mdpi.com
Chronic lung diseases are one of the leading causes of death worldwide. Lung
transplantation is currently the only causal therapeutic for lung diseases, which is restricted …

BMPR2 mutations and endothelial dysfunction in pulmonary arterial hypertension (2017 Grover Conference Series)

A Frump, A Prewitt… - Pulmonary circulation, 2018 - journals.sagepub.com
Despite the discovery more than 15 years ago that patients with hereditary pulmonary
arterial hypertension (HPAH) inherit BMP type 2 receptor (BMPR2) mutations, it is still …

Three-Dimensional Bioprinting of Biocompatible Photosensitive Polymers for Tissue Engineering Application

J Lim, S Bupphathong, W Huang… - Tissue Engineering Part B …, 2023 - liebertpub.com
Three-dimensional (3D) bioprinting, or additive manufacturing, is a rapid fabrication
technique with the foremost objective of creating biomimetic tissue and organ replacements …