Complement in neurological disorders and emerging complement-targeted therapeutics

MC Dalakas, H Alexopoulos, PJ Spaeth - Nature Reviews Neurology, 2020 - nature.com
The complement system consists of a network of plasma and membrane proteins that
modulate tissue homeostasis and contribute to immune surveillance by interacting with the …

Complement in the brain: contributions to neuroprotection, neuronal plasticity, and neuroinflammation

SS Bohlson, AJ Tenner - Annual Review of Immunology, 2023 - annualreviews.org
The complement system is an ancient collection of proteolytic cascades with well-described
roles in regulation of innate and adaptive immunity. With the convergence of a revolution in …

Association of high-dose erythropoietin with circulating biomarkers and neurodevelopmental outcomes among neonates with hypoxic ischemic encephalopathy: A …

SE Juul, E Voldal, BA Comstock, AN Massaro… - JAMA network …, 2023 - jamanetwork.com
Importance The ability to predict neurodevelopmental impairment (NDI) for infants
diagnosed with hypoxic ischemic encephalopathy (HIE) is important for parental guidance …

Therapeutic inhibition of the complement system in diseases of the central nervous system

SM Carpanini, M Torvell, BP Morgan - Frontiers in immunology, 2019 - frontiersin.org
The complement system plays critical roles in development, homeostasis, and regeneration
in the central nervous system (CNS) throughout life; however, complement dysregulation in …

The complement system in schizophrenia: where are we now and what's next?

JJ Woo, JG Pouget, CC Zai, JL Kennedy - Molecular psychiatry, 2020 - nature.com
The complement system is a set of immune proteins involved in first-line defense against
pathogens and removal of waste materials. Recent evidence has implicated the complement …

Complement dysregulation in the central nervous system during development and disease

JD Lee, LG Coulthard, TM Woodruff - Seminars in Immunology, 2019 - Elsevier
The complement cascade is an important arm of the immune system that plays a key role in
protecting the central nervous system (CNS) from infection. Recently, it has also become …

Complement system in brain architecture and neurodevelopmental disorders

J Magdalon, F Mansur, AL Teles e Silva… - Frontiers in …, 2020 - frontiersin.org
Current evidence indicates that certain immune molecules such as components of the
complement system are directly involved in neurobiological processes related to brain …

[HTML][HTML] Significance of complement system in ischemic stroke: a comprehensive review

Y Ma, Y Liu, Z Zhang, GY Yang - Aging and disease, 2019 - ncbi.nlm.nih.gov
The complement system is an essential part of innate immunity, typically conferring
protection via eliminating pathogens and accumulating debris. However, the defensive …

Essential role of complement in pregnancy: from implantation to parturition and beyond

G Girardi, JJ Lingo, SD Fleming, JF Regal - Frontiers in immunology, 2020 - frontiersin.org
The complement cascade was identified over 100 years ago, yet investigation of its role in
pregnancy remains an area of intense research. Complement inhibitors at the maternal-fetal …

The complement system and preeclampsia

JF Regal, RM Burwick, SD Fleming - Current hypertension reports, 2017 - Springer
Abstract Purpose of Review Preeclampsia affects 3–4% of pregnancies with few treatment
options to reduce maternal and fetal harm. Recent evidence that targeting the complement …