[HTML][HTML] Why does circadian timing of administration matter for immune checkpoint inhibitors' efficacy?

A Karaboué, PF Innominato, NI Wreglesworth… - British Journal of …, 2024 - nature.com
Background Tolerability and antitumour efficacy of chemotherapy and radiation therapy can
vary largely according to their time of administration along the 24-h time scale, due to the …

Sex differences in cancer and immunotherapy outcomes: the role of androgen receptor

J Zhao, Q Wang, AF Tan, CJL Loh, HC Toh - Frontiers in Immunology, 2024 - frontiersin.org
Across the wide range of clinical conditions, there exists a sex imbalance where biological
females are more prone to autoimmune diseases and males to some cancers. These …

[HTML][HTML] Metastasis and basement membrane-related signature enhances hepatocellular carcinoma prognosis and diagnosis by integrating single-cell RNA …

S Wei, J Tan, X Huang, K Zhuang, W Qiu… - Journal of Translational …, 2024 - Springer
Background Hepatocellular carcinoma (HCC) is the most common type of primary liver
cancer and second leading cause of cancer-related deaths worldwide. The heightened …

[HTML][HTML] Sex Matters: From Bile Acid Metabolism to Liver Cancer

SKS Chauhan, B Heinrich - Cellular and Molecular …, 2024 - ncbi.nlm.nih.gov
In the current issue of Cellular and Molecular Gastro-enterology and Hepatology, Golonka et
al 1 provide new insights on “Sex Dimorphic Effects of Bile Acid Metabolism in Liver Cancer …

Effect of Subgroups on Study Outcomes in Unresectable Hepatocellular Carcinoma Undergoing Upfront Systemic Treatment: A Meta-analysis

GA Colloca, A Venturino - American Journal of Clinical Oncology - journals.lww.com
Objectives: Immunotherapy improved the outcome of patients with unresectable
hepatocellular carcinoma, but not all studies are in agreement, nor is it clear whether certain …