Radical aryl migrations are powerful techniques to forge new bonds in aromatic compounds.
The growing popularity of photoredox catalysis has led to an influx of novel strategies to …

Methods to functionalize arenes and heteroarenes in a site-selective manner are highly
sought after for rapidly constructing value-added molecules of medicinal, agrochemical, and …

The asymmetric construction of all-carbon quaternary centres within acyclic settings
represents a long-standing challenge for synthetic chemists. Alongside polar and radical …

Chemists are generally familiar with polar reactions and radical reactions, in comparison,
are underdeveloped. In the last few years, however, the novel concept of amalgamation of …

Recent developments in experimental and computational chemistry have identified a rapidly
growing class of nucleophilic aromatic substitutions that proceed by concerted (cSNAr) …

Conspectus The asymmetric synthesis of heavily substituted benzylic stereogenic centers,
prevalent in natural products, therapeutics, agrochemicals, and catalysts, is an ongoing …

The requirement of higher reaction temperatures for an SNAr reaction between thiols and
less reactive electron-poor aryl halides described in earlier reports has triggered intensive …

Chiral organosulfur compounds are not only widely distributed in bioactive natural products
and pharmaceuticals, but also play a significant role in chiral ligands/catalysts. Throughout …

We report the results of computational modeling of the reactions of the SARS-CoV-2 main
protease (MPro) with four potential covalent inhibitors. Two of them, carmofur and …

A short, atroposelective synthesis of cihunamide B (1) is reported. The feature of this report
is the decagram-scale SNAr reaction of l-tryptophan derivatives, followed by atroposelective …