The persistence of increased excitability and spontaneous activity in injured peripheral
neurons is imperative for the development and persistence of many forms of neuropathic …

Voltage-dependent ion channels regulate the opening of their pores by sensing the
membrane voltage. This process underlies the propagation of action potentials and other …

The hyperpolarization-activated cyclic nucleotide-gated (HCN) channel is a voltage-gated
cation channel that mediates neuronal and cardiac pacemaker activity. The HCN channel …

Hyperpolarization-activated cyclic nucleotide–gated (HCN) channels are expressed as four
different isoforms (HCN1-4) in the heart and in the central and peripheral nervous systems …

Background Hyperpolarization-activated cyclic nucleotide-gated (HCN) current reduces
dendritic summation, suppresses dendritic calcium spikes, and enables inhibitory GABA …

Oligodendrocytes generate myelin sheaths vital for the formation, health, and function of the
CNS. Myelin sheath length is a key property that determines axonal conduction velocity and …

Cardiac remodeling can cause ventricular dysfunction and progress to heart failure, a
cardiovascular disease that claims many lives globally. Ivabradine, a funny channel (I f) …

A plethora of studies indicate the important role of cAMP and cGMP cascades in neuronal
plasticity and memory function. As a result, altered cyclic nucleotide signaling has been …

Abstract Chemotherapy-Induced Peripheral Neuropathy (CIPN) is the most frequent adverse
effect of pharmacological cancer treatments. The occurrence of neuropathy prevents the …

Abstract Properties of the funny current (I f) have been studied in several animal and cellular
models, but so far little is known concerning its properties in human pacemaker cells. This …