Due to evolutionary conservation of biology, experimental knowledge captured from genetic
studies in eukaryotic model organisms provides insight into human cellular pathways and …

Changes in protein–protein interactions that occur in response to environmental cues are
difficult to uncover and have been poorly characterized to date. Here we describe a yeast …

Understanding how novel antifungal compounds work in target cells is useful not only in
facilitating the discovery of new drugs but also new tools that can be used for further …

Resistance to camptothecin (CPT), a topoisomerase I (Top1) inhibitor, is frequently
encountered in non-small cell lung cancer (NSCLC) and CPT resistance is linked with …

The chemotherapeutic doxorubicin (DOX) induces DNA double-strand break (DSB)
damage. In order to identify conserved genes that mediate DOX resistance, we screened the …

We searched for F-box proteins that might be related to the mechanism that protects
Saccharomyces cerevisiae against the toxic effects of methylmercury. We found that …

To elucidate the mechanism of acquired resistance to Adriamycin, we searched for genes
that, when overexpressed, render Saccharomyces cerevisiae resistant to Adriamycin. We …

Resistance to cancer therapy is a major obstacle in the long-term treatment of cancer. A
greater understanding of drug resistance mechanisms will ultimately lead to the …

In a search for undiscovered mechanisms of resistance to adriamycin, we screened a
genomic library derived from Saccharomyces cerevisiae for genes related to adriamycin …

We have found that, in the yeast Saccharomyces cerevisiae, overexpression of the DNA
helicase Ssl2p confers resistance to adriamycin. Ssl2p is involved, as a subunit of the basic …