Novel niosome-encapsulated 2, 5-diketopiperazine (BHPPD): Synthesis, formulation, and anti-breast cancer activity

H Ghourchian, RDC Pecho, M Karimi-Dehkordi… - Applied Biochemistry …, 2023 - Springer
In the course of this investigation, a brand-new noisome-encapsulated 2, 5-diketopiperazine
(BHPPD) was developed, synthesized, and assessed. Utilizing CCK-8, invasion screens …

Current treatment strategies for targeting virulence factors and biofilm formation in Acinetobacter baumannii

SL Rajangam, MK Narasimhan - Future Microbiology, 2024 - Taylor & Francis
A higher prevalence of Acinetobacter baumannii infections and mortality rate has been
reported recently in hospital-acquired infections (HAI). The biofilm-forming capability of A …

[HTML][HTML] Oral administration of DNA alginate nanovaccine induced immune-protection against Helicobacter pylori in Balb/C mice

A Kaveh-Samani, S Dalali, F Kaviani, T Piri-Gharaghie… - BMC immunology, 2024 - Springer
Abstract Background Helicobacter pylori (H. Pylori), is an established causative factor for the
development of gastric cancer and the induction of persistent stomach infections that may …

[HTML][HTML] Use of immunoinformatics and the simulation approach to identify Helicobacter pylori epitopes to design a multi-epitope subunit vaccine for B- and T-cells

ZA Chaleshtori, AA Rastegari, H Nayeri, A Doosti - BMC biotechnology, 2023 - Springer
Background Helicobacter pylori cause a variety of gastric malignancies, gastric ulcers, and
cause erosive diseases. The extreme nature of the bacterium and the implantation of this …

[HTML][HTML] PIRES2-EGFP/CTB-UreI vaccination activated a mixed Th1/Th2/Th17 immune system defense towards Helicobacter pylori infection in the BALB/c mice model

S Ghasemifar, O Chabak, T Piri-Gharaghie, A Doosti - Vaccine, 2024 - Elsevier
The occurrence of gastritis, gastric ulcers, distal gastric cancer, and gastric mucosal
lymphoma in humans is strongly associated with Helicobacter pylori (H. pylori). Vaccination …

Brucella abortus antigen omp25 vaccines: Development and targeting based on Lactococcus lactis

ST Gouran, A Doosti, MS Jami - Veterinary Medicine and …, 2023 - Wiley Online Library
Abstract Background Most Brucella infections take place on mucosal membranes. Therefore,
creating vaccinations delivered through the mucosa may be crucial for managing …

Chitosan-LeoA-DNA Nanoparticles Promoted the Efficacy of Novel LeoA-DNA Vaccination on Mice Against Helicobacter pylori

ZA Chaleshtori, AA Rastegari, H Nayeri, A Doosti - Current Microbiology, 2024 - Springer
More than half of the world's population is infected with Helicobacter pylori (H. pylori), which
may lead to chronic gastritis, peptic ulcers, and stomach cancer. LeoA, a conserved antigen …

In vivo immunological activity of chitosan-derived nanoparticles

C Xu, R Xing, S Liu, Y Qin, K Li, H Yu, P Li - International Journal of …, 2024 - Elsevier
Chitosan has been studied as an immunomodulator, but few studies have used chitosan
derivatives as adjuvants alone. After a preliminary study, we found that nanoparticles …

A novel vaccine strategy against Brucellosis using Brucella abortus multi-epitope OMPs vaccine based on Lactococcus lactis live bacterial vectors

T Piri-Gharaghie, G Ghajari, G Rezaeizadeh… - International …, 2024 - Elsevier
Brucella infections typically occur in mucosal membranes, emphasizing the need for
mucosal vaccinations. This study evaluated the effectiveness of orally administering …

[HTML][HTML] Putative novel outer membrane antigens multi-epitope DNA vaccine candidates identified by Immunoinformatic approaches to control Acinetobacter …

NS Tabibpour, A Doosti, A Sharifzadeh - BMC immunology, 2023 - Springer
Multi-epitope polypeptide vaccines, a fusion protein, often have a string-of-beads system
composed of various specific peptide epitopes, potential adjuvants, and linkers. When …