DNA methylation and healthy human aging
The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …
include senescence, telomere shortening, and changes in gene expression. Epigenetic …
[HTML][HTML] Smoking and male infertility: an evidence-based review
Many studies have reported that the contents of cigarette smoke negatively affect sperm
parameters, seminal plasma, and various other fertility factors. Nevertheless, the actual …
parameters, seminal plasma, and various other fertility factors. Nevertheless, the actual …
[PDF][PDF] DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis
Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
environmental impacts on human disease. Maternal smoking in pregnancy remains an …
[HTML][HTML] Tobacco smoking leads to extensive genome-wide changes in DNA methylation
S Zeilinger, B Kühnel, N Klopp, H Baurecht… - PloS one, 2013 - journals.plos.org
Environmental factors such as tobacco smoking may have long-lasting effects on DNA
methylation patterns, which might lead to changes in gene expression and in a broader …
methylation patterns, which might lead to changes in gene expression and in a broader …
450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy
Background: Epigenetic modifications, such as DNA methylation, due to in utero exposures
may play a critical role in early programming for childhood and adult illness. Maternal …
may play a critical role in early programming for childhood and adult illness. Maternal …
Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children …
Maternal smoking during pregnancy has been found to influence newborn DNA methylation
in genes involved in fundamental developmental processes. It is pertinent to understand the …
in genes involved in fundamental developmental processes. It is pertinent to understand the …
Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci
EW Demerath, W Guan, ML Grove… - Human molecular …, 2015 - academic.oup.com
Obesity is an important component of the pathophysiology of chronic diseases. Identifying
epigenetic modifications associated with elevated adiposity, including DNA methylation …
epigenetic modifications associated with elevated adiposity, including DNA methylation …
Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation
Smoking is a major risk factor in many diseases. Genome wide association studies have
linked genes for nicotine dependence and smoking behavior to increased risk of …
linked genes for nicotine dependence and smoking behavior to increased risk of …
[HTML][HTML] Cigarette smoking and DNA methylation
KWK Lee, Z Pausova - Frontiers in genetics, 2013 - frontiersin.org
DNA methylation is the most studied epigenetic modification, capable of controlling gene
expression in the contexts of normal traits or diseases. It is highly dynamic during early …
expression in the contexts of normal traits or diseases. It is highly dynamic during early …
[HTML][HTML] DNA methylation biomarkers: cancer and beyond
Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …
or disease can be identified or monitored. They can reflect past environmental exposures …