Extrachromosomal DNA (ecDNA) has recently been recognized as a major contributor to
cancer pathogenesis that is identified in most cancer types and is associated with poor …

Cancer treatment faces many hurdles and resistance is one among them. Anti-cancer
treatment strategies are evolving due to innate and acquired resistance capacity, governed …

Cancer is a complex disease displaying a variety of cell states and phenotypes. This
diversity, known as cancer cell plasticity, confers cancer cells the ability to change in …

Simple Summary Increasing number of cancer patients and significant mortality among
these patients are attributed to many factors including anticancer drug resistance. Among a …

If one must prioritize among the vast array of contributing factors to cancer evolution,
environmental-stress-mediated chromosome instability (CIN) should easily surpass …

Striving to understand the mechanisms of cancer evolution is crucial for both basic cancer
research and for clinical applicability. Cancer represents somatic evolution as it always …

Objective Limited availability of authentic human adenoid cystic carcinoma (ACC) cell lines
has hindered progress in understanding mechanisms underpinning the biology of this …

The highly conserved Notch pathway is important, as it is a regulator of self-renewal and
differentiation. The Notch pathway is responsible for aberrant epigenetic modification …

Chromosome abnormalities are a leading cause of pregnancy loss, developmental delays,
and birth defects. These abnormalities arise from errors in chromosome structure (breakage) …

The complex structures in cancer genomes are obtained through the revolution of high-
throughput technology. The major challenge involves the interpretation of complex …