Polyunsaturated fatty acids are susceptible to peroxidation and they yield various
degradation products, including the main α, β-unsaturated hydroxyalkenal, 4-hydroxy-2, 3 …

Since the original identification of microglia as a principal player in the brain's innate
immune response, microglial activation has been widely studied. Recent studies suggest …

As a result of deprivation of oxygen (hypoxia) and nutrients, the growth and viability of cells
is reduced. Hypoxia-inducible factor (HIF)-1α helps to restore oxygen homeostasis by …

Background Adjuvant chemotherapy improves survival among patients with stage III colon
cancer, but no reliable molecular predictors of outcome have been identified. Methods We …

Background Organisms simplify the orchestration of gene expression by coregulating genes
whose products function together in the cell. Many proteins serve different roles depending …

The ability of neurons to regenerate an axon after injury is determined by both the
surrounding environment and factors intrinsic to the damaged neuron. We have used cDNA …

Apoptosis is a fundamental mechanism of cell death that can be engaged by a range of
cellular insults. One of the major modes of action of chemotherapeutic drugs may be via the …

Despite the high number of previous studies, the role of p53 alterations in prostate cancer is
not clearly defined. To address the role of p53 alterations in prostate cancer biology, a total …

In recent years, the incidence rate of breast cancer has increased year by year, and it has
become a major threat to the health of women globally. Among all breast cancer subtypes …

As a broad-acting cyclin-dependent kinase inhibitor, p21WAF1 occupies a central position in
the cell cycle regulation of self-renewing tissues such as oral mucosa and skin. In addition to …