Nitrogen‐containing heterocyclic scaffolds have become a prospective pharmacophore with
therapeutic importance due to their biological similarities with natural and synthetic drugs …

Blood coagulation is the process of changing the blood from the flowing state to the gel
state. It is an important part of the hemostatic function. Coagulation is a process by which a …

The first iridium-catalyzed enantioselective intramolecular allylic aminations of
benzimidazole-tethered allylic carbonates were developed, providing three classes of …

An efficient method for the synthesis of [1, 2, 4] triazolo [4, 3-a] piperazine derivatives was
established based on a gold (I)-catalyzed domino cyclization of an amidrazone substrate …

Abstract Ten derivatives of 4-((1, 2, 3, 4-tetrahydrobenzo [4, 5] imidazo [1, 2-a] pyrazin-1-yl)
methyl) benzimida-mide (I-1∼ I-2, II-1∼ II-8) were designed, synthesized and evaluated for …

Thrombin is a serine protease that plays a key role in blood clotting, which makes it a
promising target for the treatment of thrombotic diseases. Dabigatran is direct potent …

Benzoxazole and benzimidazole are commonly encountered heterocycles in medicinal
chemistry and their functionalisation around 1-, 2-, 5-, and/or 6-positions provides a wide …

ABSTRACT Direct Coagulase Inhibitors category of medication that acts as anticoagulants
(delaying blood clotting) by directly inhibiting the accelerator coagulase (factor II a) …