Airway microbiome-immune crosstalk in chronic obstructive pulmonary disease

A Kayongo, NM Robertson, T Siddharthan… - Frontiers in …, 2023 - frontiersin.org
Chronic Obstructive Pulmonary Disease (COPD) has significantly contributed to global
mortality, with three million deaths reported annually. This impact is expected to increase …

[HTML][HTML] Decoding the role of S100 proteins in mammary gland regulation and their role in breast cancer metastasis

P Singh, SA Ali - Advances in Cancer Biology-Metastasis, 2023 - Elsevier
S100 proteins have emerged as key regulators in the mammary gland and have been
implicated in breast cancer development and metastasis. This review provides a …

Calcium-bound S100P protein is a promiscuous binding partner of the four-helical cytokines

AS Kazakov, EI Deryusheva, ME Permyakova… - International journal of …, 2022 - mdpi.com
S100 proteins are multifunctional calcium-binding proteins of vertebrates that act
intracellularly, extracellularly, or both, and are engaged in the progression of many socially …

Silicone implant surface microtopography modulates inflammation and tissue repair in capsular fibrosis

I Schoberleitner, K Faserl, CH Tripp… - Frontiers in …, 2024 - frontiersin.org
Excessive fibrous capsule formation around silicone mammary implants (SMI) involves
immune reactions to silicone. Capsular fibrosis, a common SMI complication linked to host …

Interaction of S100A6 protein with the four-helical cytokines

AS Kazakov, EI Deryusheva, VA Rastrygina… - Biomolecules, 2023 - mdpi.com
S100 is a family of over 20 structurally homologous, but functionally diverse regulatory
(calcium/zinc)-binding proteins of vertebrates. The involvement of S100 proteins in …

Specific S100 proteins bind tumor necrosis factor and inhibit its activity

AS Kazakov, MY Zemskova, GK Rystsov… - International Journal of …, 2022 - mdpi.com
Tumor necrosis factor (TNF) inhibitors (anti-TNFs) represent a cornerstone of the treatment
of various immune-mediated inflammatory diseases and are among the most commercially …

RAGE pathway activation and function in chronic kidney disease and COVID-19

CS Curran, JB Kopp - Frontiers in Medicine, 2022 - frontiersin.org
The multi-ligand receptor for advanced glycation end-products (RAGE) and its ligands are
contributing factors in autoimmunity, cancers, and infectious disease. RAGE activation is …

Proteomics-based mapping of bronchopulmonary dysplasia-associated changes in noninvasively accessible oral secretions

S Ahmed, OA Odumade, P van Zalm, B Fatou… - The Journal of …, 2024 - Elsevier
Objective To determine if oral secretions (OS) can be used as a noninvasively collected
body fluid, in lieu of tracheal aspirates (TA), to track respiratory status and predict …

[HTML][HTML] Human‐host transcriptomic analysis reveals unique early innate immune responses in different sub‐phenotypes of COVID‐19

R Maurya, U Shamim, P Chattopadhyay… - Clinical and …, 2022 - ncbi.nlm.nih.gov
Dear Editor, The diverse clinical manifestations of COVID-19 are substantially modulated by
host immune responses, emphasising the need for investigating the initial Transcriptional …

High-throughput Extracellular Matrix Proteomics of Human Lungs Enabled by Photocleavable Surfactant and diaPASEF

EF Bayne, KM Buck, AG Towler, Y Zhu… - Journal of Proteome …, 2024 - ACS Publications
The extracellular matrix (ECM) is a complex assembly of proteins that provide interstitial
scaffolding and elastic recoil for human lungs. The pulmonary extracellular matrix is …