In higher eukaryotes, fine-tuned activation of protein-coding genes and many non-coding
RNAs pivots around the regulated activity of RNA polymerase II (Pol II). The Integrator …

Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for
chromosomal pairing and exchange during meiosis. However, some forms of HR can also …

The proper regulation of transcription is essential for maintaining genome integrity and
executing other downstream cellular functions,. Here we identify a stable association …

Genome integrity is constantly monitored by sophisticated cellular networks, collectively
termed the DNA damage response (DDR). A common feature of DDR proteins is their …

The occurrence of DNA double-strand breaks (DSBs) induced by ionizing radiation has
been extensively studied by biochemical or cell imaging techniques. Cell imaging …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

BACKGROUND & AIMS: Heritable factors contribute to the development of colorectal
cancer. Identifying the genetic loci associated with colorectal tumor formation could …

Like their nuclear counterpart, the plastid and mitochondrial genomes of plants have to be
faithfully replicated and repaired to ensure the normal functioning of the plant. Inability to …

Loss or rearrangement of genetic information can result from incorrect responses to DNA
double strand breaks (DSBs). The cellular responses to DSBs encompass a range of highly …

Abstract 5′ strand resection at DNA double strand breaks (DSBs) is critical for homologous
recombination (HR) and genomic stability. Here we develop a novel method to quantitatively …