Chronic obstructive pulmonary disease (COPD) includes chronic bronchitis, emphysema,
and small airway obstruction. Incompletely reversible airflow limitation, inflammation …

Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade proteins of the
extracellular matrix and the basement membrane. Thus, these enzymes regulate airway …

Chronic obstructive pulmonary disease (COPD) is the third leading cause of mortality
globally and the risk of developing lung cancer is six times greater in individuals with COPD …

Simple Summary Multifactorial diseases are caused by a combination of genetic and
environmental factors and various risk factors that accumulate with age. Cardiovascular …

Elastin is a crucial extracellular matrix protein that provides structural integrity to tissues.
Crosslinked elastin and associated microfibrils, named elastic fiber, contribute to …

Chronic obstructive pulmonary disease (COPD) is a gradually worsening and fatal
heterogeneous lung disease characterized by airflow limitation and increasingly decline in …

Non-emphysematous chronic obstructive pulmonary disease (COPD), which is defined
based on chest computed tomography findings, presented different transcriptome features of …

Introduction Cigarette smoke triggers many cellular and signaling responses in the lung and
the resulting inflammation plays a central role in smoke-related lung diseases, such as …

Necroptosis has emerged as one of the crucial pathological processes involved in the
regulation of cell death and inflammation in chronic obstructive pulmonary disease (COPD) …

Lung disease progression in alpha-1 antitrypsin deficiency (AATD) is heterogenous and
manifests in different ways. Blood biomarkers are an attractive method of monitoring …