With a 3‐fold increase in the number of cancer survivors noted since the 1970s, there are
now over 28 million cancer survivors worldwide. Accordingly, there is a heightened …

Neurotoxic anticancer drugs, such as platinum-based anticancer drugs, taxanes, vinca
alkaloids, and proteasome/angiogenesis inhibitors are responsible for chemotherapy …

Vincristine-induced peripheral neurotoxicity (VIPN) is a very common side effect of
vincristine chemotherapy among pediatric patients with cancer. Neuropathy may be sensory …

Peripheral neuropathies induced by chemotherapy (CIPN) are an increasingly frequent
problem. Contrary to hematologic adverse effects, which can be treated with hematopoetic …

Importance With cure rates of childhood acute lymphoblastic leukemia (ALL) exceeding
85%, there is a need to mitigate treatment toxicities that can compromise quality of life …

Interindividual variability in drug disposition is a major cause of lack of efficacy and adverse
effects of drug therapies. The majority of hepatically cleared drugs are metabolized by …

Cytochrome P450 (CYP) enzymes are responsible for the biotransformation of drugs,
xenobiotics, and endogenous substances. This enzymatic activity can be modulated by …

Vincristine is a chemotherapeutic agent that is a component of many combination regimens
for a variety of malignancies, including several common pediatric tumors. Vincristine …

Vincristine-induced peripheral neuropathy (VIPN) is a dose-limiting side effect of vincristine
(VCR) treatment in children, leading to diminished quality of life. Much remains unknown …

The intensified administration of chemotherapeutic drugs has gradually replaced cranial
radiation therapy (CRT) for the treatment of childhood acute lymphoblastic leukemia (ALL) …