In general, heterocyclic compounds are a significant source of pharmacologically active
compounds. Among them, the indole scaffold widely distributes in natural products and …

A wealth of evidence supports the role of tumor immunotherapy as a vital therapeutic option
in cancer. In recent decades, accumulated studies have revealed the anticancer activities of …

Paclitaxel is a well known anticancer compound. Its biosynthesis involves the formation of a
highly functionalized diterpenoid core skeleton (baccatin III) and the subsequent assembly …

Tumor biomarker‐based theranostics have achieved broad interest and success in recent
years. However, single biomarker‐based recognition can cause false‐positive feedback …

Highlights•Colchicine binding site inhibitors (CBSIs) emerge as new generations of tubulin
inhibitors.•CBSIs are less susceptible to multidrug resistance than FDA-approved tubulin …

Abstract Coronavirus virus disease 2019 (COVID-19) is a viral infectious disease caused by
the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), actually considered as …

Lung cancer is the leading cause of death in men and women worldwide, affecting millions
of people. Between the two types of lung cancers, non-small cell lung cancer (NSCLC) is …

Maytansine is a pharmacologically active 19-membered ansamacrolide derived from
various medicinal plants and microorganisms. Among the most studied pharmacological …

Mitotic catastrophe is distinct from other cell death modes due to unique nuclear alterations
characterized as multi and/or micronucleation. Mitotic catastrophe is a common and virtually …

Targeted protein degradation (TPD) has emerged as the most promising approach for the
specific knockdown of disease-associated proteins and is achieved by exploiting the cellular …