The structural basis of pyridoxal-5′-phosphate-dependent β-NAD-alkylating enzymes
SbzP is a unique pyridoxal-5′-phosphate-dependent enzyme, which catalyses a [3+ 2]
annulation between the pyridinium ring of β-nicotinamide adenine dinucleotide (β-NAD) and …
annulation between the pyridinium ring of β-nicotinamide adenine dinucleotide (β-NAD) and …
Fc-independent SARS-CoV-2 infection-enhancing antibodies decouple N-terminal and receptor-binding domains by cross-linking neighboring spikes
FJ van Eerden, S Li, T Lusiany, HS Ismanto, T Terada… - bioRxiv, 2024 - biorxiv.org
Antibody dependent enhancement (ADE) is a serious concern in vaccine development. The
canonical ADE pathways are dependent on the fragment crystallizable (Fc) region of the …
canonical ADE pathways are dependent on the fragment crystallizable (Fc) region of the …
Phase Separation-based Antiviral Decoy Particles as Basis for Programmable Broad-spectrum Therapeutics
To gain access to cells, viruses employ host proteins as receptors. In soluble form, these
receptors are used as decoys to inhibit infection. We fused candidate soluble receptors to an …
receptors are used as decoys to inhibit infection. We fused candidate soluble receptors to an …