The unprecedented pandemic of the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) is threatening global health. The virus emerged in late 2019 and can cause a …

In this work, the discovery and description of PF‐07321332, a major bioavailable oral SARS‐
CoV‐2 protease inhibitor with in vitro human coronavirus antiviral activity, and excellent …

We prepared the three-dimensional model of the SARS-CoV-2 (aka 2019-nCoV) 3C-like
protease (3CL pro) using the crystal structure of the highly similar (96% identity) ortholog …

The COVID-19 disease caused by the SARS-CoV-2 coronavirus has become a pandemic
health crisis. An attractive target for antiviral inhibitors is the main protease 3CL Mpro due to …

COVID-19 has become a global pandemic and there is an urgent call for developing drugs
against the virus (SARS-CoV-2). The 3C-like protease (3CLpro) of SARS-CoV-2 is a …

A new coronavirus (CoV) caused a pandemic named COVID-19, which has become a
global health care emergency in the present time. The virus is referred to as SARS-CoV-2 …

Recently emerged SARS-CoV-2 caused a major outbreak of coronavirus disease 2019
(COVID-19) and instigated a widespread fear, threatening global health safety. To date, no …

Severe acute respiratory syndrome (SARS) is caused by a newly emerged coronavirus that
infected more than 8000 individuals and resulted in more than 800 (10–15%) fatalities in …

The uncontrolled spread of the COVID-19 pandemic caused by the new coronavirus SARS-
CoV-2 during 2020–2021 is one of the most devastating events in the history, with …

The main protease (Mpro) is a validated antiviral drug target of SARS-CoV-2. A number of
Mpro inhibitors have now advanced to animal model study and human clinical trials …