Colorectal cancer (CRC) is one of the most prevalent and deadly cancers worldwide.
Despite recent improvements in treatment and prevention, most of the current therapeutic …

Despite advances in screening and therapeutics cancer continues to be one of the major
causes of morbidity and mortality worldwide. The molecular profile of tumor is routinely …

Abstract Purpose: ERBB2 (HER2) amplification is an emerging biomarker in colon cancer,
conferring sensitivity to combination anti-HER2 therapy. Measurement of HER2 copy …

Purpose: Molecular tumor heterogeneity may have important implications for the efficacy of
targeted therapies in metastatic cancers. Inter-metastatic heterogeneity of sensitivity to …

Purpose: High-grade serous epithelial ovarian cancer (HGS-EOC) is defined by high levels
of somatic copy-number alterations (SCNA) with marked spatial and temporal tumor …

Liquid biopsy of circulating tumor cells (CTC) and circulating tumor DNA (ct DNA) is gaining
attention as a method for real‐time monitoring in cancer patients. Conventional methods …

Purpose: We conducted a pilot study to assess the feasibility and the potential implications
of detecting TERT promoter (TERT p)–mutant cell-free tumor-derived DNA (tDNA) in the …

Liquid biopsy has become a useful alternative in metastatic colorectal cancer (mCRC)
patients when tissue biopsy of metastatic sites is not feasible. In this study we aimed to …

Cells can communicate through special “messages in the bottle”, which are recorded in the
bloodstream inside vesicles, namely exosomes. The exosomes are nanovesicles of 30–100 …

Introduction: Liquid biopsies have attracted considerable attention as potential diagnostic,
prognostic, predictive, and screening assays in oncology. The term liquid biopsies include …