The C. elegans insulin/IGF-1 signaling (IIS) pathway connects nutrient levels to metabolism,
growth, development, longevity, and behavior. This fundamental pathway is regulated by …

The power of any genetic model organism is derived, in part, from the ease with which gene
expression can be manipulated. The short generation time and invariant developmental …

The biology and behavior of adults differ substantially from those of developing animals, and
cell-specific information is critical for deciphering the biology of multicellular animals. Thus …

Protein damage contributes prominently to cellular aging. To address whether this occurs at
a specific period during aging or accumulates gradually, we monitored the biochemical …

Connectomics has focused primarily on the mapping of synaptic links in the brain; yet it is
well established that extrasynaptic volume transmission, especially via monoamines and …

The nematode C. elegans is attracted to nutritious bacteria and is repelled by pathogens
and toxins. Here we show that RNAi and toxin-mediated disruption of core cellular activities …

Proteasomes are essential for protein homeostasis in eukaryotes. To preserve cellular
function, transcription of proteasome subunit genes is induced in response to proteasome …

How genes are regulated to produce the correct assortment of proteins for every cell type is
a fundamental question in biology. For many genes, regulation begins at the DNA level with …

The C. elegans genome has been completely sequenced, and the developmental anatomy
of this model organism is described at single-cell resolution. Here we utilize strategies that …

Extended longevity is often correlated with increased resistance against various stressors.
Insulin/IGF-1-like signaling (IIS) is known to have a conserved role in aging and cellular …