Influence of glycosylation on the immunogenicity and antigenicity of viral immunogens
A key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies
targeting viral attachment and fusion glycoproteins that embellish viral particles. This …
targeting viral attachment and fusion glycoproteins that embellish viral particles. This …
Germline-targeting HIV-1 Env vaccination induces VRC01-class antibodies with rare insertions
Targeting germline (gl-) precursors of broadly neutralizing antibodies (bNAbs) is
acknowledged as an important strategy for HIV-1 vaccines. The VRC01-class of bNAbs is …
acknowledged as an important strategy for HIV-1 vaccines. The VRC01-class of bNAbs is …
A combined adjuvant approach primes robust germinal center responses and humoral immunity in non-human primates
Adjuvants and antigen delivery kinetics can profoundly influence B cell responses and
should be critically considered in rational vaccine design, particularly for difficult neutralizing …
should be critically considered in rational vaccine design, particularly for difficult neutralizing …
Mutation-guided vaccine design: A process for developing boosting immunogens for HIV broadly neutralizing antibody induction
A major goal of HIV-1 vaccine development is the induction of broadly neutralizing
antibodies (bnAbs). Although success has been achieved in initiating bnAb B cell lineages …
antibodies (bnAbs). Although success has been achieved in initiating bnAb B cell lineages …
Mutation-guided vaccine design: a strategy for developing boosting immunogens for HIV broadly neutralizing antibody induction
A major goal of HIV-1 vaccine development is induction of broadly neutralizing antibodies
(bnAbs). While success has been achieved in initiating bnAb B cell lineages, design of …
(bnAbs). While success has been achieved in initiating bnAb B cell lineages, design of …
[HTML][HTML] B cell somatic hypermutation following COVID-19 vaccination with Ad26. COV2. S
C Jacob-Dolan, M Lifton, OC Powers, J Miller… - Iscience, 2024 - cell.com
The viral vector-based COVID-19 vaccine Ad26. COV2. S has been recommended by the
WHO since 2021 and has been administered to over 200 million people. Prior studies have …
WHO since 2021 and has been administered to over 200 million people. Prior studies have …
HIV-1 neutralizing antibodies in SHIV-infected macaques recapitulate structurally divergent modes of human V2 apex recognition with a single D gene
Broadly neutralizing antibodies targeting the V2 apex of the HIV-1 envelope trimer are
among the most common specificities elicited in HIV-1-infected humans and simian-human …
among the most common specificities elicited in HIV-1-infected humans and simian-human …
HIV Vaccine Trials in Thailand and Path to HIV Cure.
A Leelarasamee, S Yoksan, R Sutthent… - Journal of the …, 2022 - search.ebscohost.com
Thailand has had over 30 years of experiences and development in fighting HIV/AIDS with
successful results in terms of providing access to prevention, testing, antiretroviral treatment …
successful results in terms of providing access to prevention, testing, antiretroviral treatment …