Interleukin-10 (IL-10), first recognized for its ability to inhibit activation and effector function of
T cells, monocytes, and macrophages, is a multifunctional cytokine with diverse effects on …

Interferon-γ (IFN-γ) is an important mediator of immunity and inflammation that utilizes the
JAK-STAT signaling pathway to activate the STAT1 transcription factor. Many functions of …

The anti-inflammatory cytokines are a series of immunoregulatory molecules that control the
proinflammatory cytokine response. Cytokines act in concert with specific cytokine inhibitors …

Excessive or persistent proinflammatory cytokine production plays a central role in
autoimmune diseases. Acute activation of the sympathetic nervous system attenuates the …

Tumor immune surveillance and cancer immunotherapies are thought to depend on the
intratumoral infiltration of activated CD8+ T cells. Intratumoral CD8+ T cells are rare and lack …

Interleukin (IL)-10 is an important immunoregulatory cytokine produced by many cell
populations. Its main biological function seems to be the limitation and termination of …

Highlights•IL-10 inhibits T cell activation by suppressing APC function.•IL-10 suppresses
TLR-signaling in dendritic cells and monocytes/macrophages.•IL-10 suppresses IFNγ …

Classification of cytokines as pro-versus anti-inflammatory might not apply to the pleiotropic
effects of interleukin-10 (IL-10). Several reports suggest that IL-10 enhances the function of …

Fever is a complex physiologic response triggered by infectious or aseptic stimuli.
Elevations in body temperature occur when concentrations of prostaglandin E2 (PGE2) …

Background & Aims: Interleukin (IL)-10 is a cytokine with potent anti-inflammatory properties.
We investigated the safety and efficacy of different doses of human recombinant (rhu) IL-10 …