Leishmania treatment and prevention: Natural and synthesized drugs
AA Bekhit, E El-Agroudy, A Helmy, TM Ibrahim… - European journal of …, 2018 - Elsevier
Leishmaniasis affects over 150 million people all over the world, especially in subtropical
regions. Currently used antileishmanial synthesized drugs are associated with some …
regions. Currently used antileishmanial synthesized drugs are associated with some …
Insights into the current status of privileged N-heterocycles as antileishmanial agents
Leishmania, one of the most important neglected tropical diseases, is endemic in several
regions of the world and hence regarded as a serious threat to public health. Major …
regions of the world and hence regarded as a serious threat to public health. Major …
Green synthesis, antileishmanial activity evaluation, and in silico studies of new amino acid-coupled 1, 2, 4-triazoles
AM El-Saghier, MA Mohamed, OA Abd-Allah… - Medicinal Chemistry …, 2019 - Springer
Candidates of triazole-containing amino acid derivatives 5a− k were prepared under green
chemistry conditions via multicomponent reaction using lemon juice as an acidic catalyst. All …
chemistry conditions via multicomponent reaction using lemon juice as an acidic catalyst. All …
Synthesis, antimalarial, antileishmanial evaluation, and molecular docking study of some 3-aryl-2-styryl substituted-4(3H)-quinazolinone derivatives
Quinazolinones are a diverse group of nitrogen-containing heterocyclic compounds with
promising antimalarial and antileishmanial activities. Herein, some 3-aryl-2-styryl substituted …
promising antimalarial and antileishmanial activities. Herein, some 3-aryl-2-styryl substituted …
Antioxidant and Cytotoxic Activity of New Polyphenolic Derivatives of Quinazolin-4 (3H)-one: Synthesis and In Vitro Activities Evaluation
The development of hybrid molecules with significant human therapeutic properties is one of
the main approaches of pharmaceutical research. One of the most important …
the main approaches of pharmaceutical research. One of the most important …
In vivo antimalarial evaluation of some 2,3-disubstituted-4(3H)-quinazolinone derivatives
Background Malaria is a neglected tropical parasitic disease affecting billons of people
around the globe. Though the number of cases and deaths associated with malaria are …
around the globe. Though the number of cases and deaths associated with malaria are …
Design, synthesis, structure-activity relationship and mechanism of action studies of a series of 4-chloro-1-phthalazinyl hydrazones as a potent agent against …
AH Romero, R Medina, A Alcala… - European Journal of …, 2017 - Elsevier
With the aim to identify a potential drug candidate to treat cutaneous leishmaniasis, a series
of 1-phthalazinyl hydrazones were synthesized and tested against Leishmania braziliensis …
of 1-phthalazinyl hydrazones were synthesized and tested against Leishmania braziliensis …
2-Aryl-quinazolin-4 (3H)-ones as an inhibitor of leishmania folate pathway: In vitro biological evaluation, mechanism studies and molecular docking
AH Romero, N Rodríguez, H Oviedo - Bioorganic Chemistry, 2019 - Elsevier
To identify new agents for the American Cutaneous Leishmaniasis treatment, a series of 2-
aryl-quinazolin-4 (3H)-ones were tested against L. mexicana, L. braziliensis and L …
aryl-quinazolin-4 (3H)-ones were tested against L. mexicana, L. braziliensis and L …
One-Pot Three-Component Reaction for the Synthesis of 3,4-Dihydroquinazolines and Quinazolin-4(3H)-ones
S Chen, YS Ji, Y Choi, SW Youn - The Journal of Organic …, 2024 - ACS Publications
A highly efficient and straightforward one-pot synthesis of diversely substituted 3, 4-
dihydroquinazolines and quinazolin-4 (3 H)-ones has been achieved through a domino …
dihydroquinazolines and quinazolin-4 (3 H)-ones has been achieved through a domino …
Synthesis, antileishmanial, antimalarial evaluation and molecular docking study of some hydrazine-coupled pyrazole derivatives
Pyrazole-bearing compounds are known for their diverse pharmacological effects including
potent antileishmanial and antimalarial activities. Herein, some hydrazine-coupled …
potent antileishmanial and antimalarial activities. Herein, some hydrazine-coupled …