T cell dynamics in HIV-1 infection

DC Douek, LJ Picker, RA Koup - Annual review of immunology, 2003 - annualreviews.org
▪ Abstract In the absence of antiretroviral treatment, HIV-1 establishes a chronic, progressive
infection of the human immune system that invariably, over the course of years, leads to its …

Antiretroviral treatment for adult HIV infection in 2002: updated recommendations of the International AIDS Society-USA Panel

PG Yeni, SM Hammer, CCJ Carpenter, DA Cooper… - Jama, 2002 - jamanetwork.com
ObjectiveNew information warrants updated recommendations for the 4 central issues in
antiretroviral therapy: when to start, what drugs to start with, when to change, and what to …

T Cell Activation Is Associated with Lower CD4+ T Cell Gains in Human Immunodeficiency Virus-Infected Patients with Sustained Viral Suppression during …

PW Hunt, JN Martin, E Sinclair, B Bredt… - The Journal of …, 2003 - academic.oup.com
Although T cell activation is associated with disease progression in untreated human
immunodeficiency virus type 1 (HIV-1) infection, its significance in antiretroviral-treated …

[图书][B] HIV and the pathogenesis of AIDS.

JA Levy - 1994 - cabidigitallibrary.org
This book grew out of a scientific review, originally published in Microbiological Reviews. It
has been updated and expanded-now citing more than 2100 references (100 pages of the …

Pathogenesis of HIV infection: what the virus spares is as important as what it destroys

Z Grossman, M Meier-Schellersheim, WE Paul… - Nature medicine, 2006 - nature.com
Upon transmission to a new host, HIV targets CCR5+ CD4+ effector memory T cells,
resulting in acute, massive depletion of these cells from mucosal effector sites. This …

CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load

AE Sousa, J Carneiro… - The Journal of …, 2002 - journals.aai.org
The causal relationships among CD4 cell depletion, HIV replication, and immune activation
are not well understood. HIV-2 infection,“nature's experiment” with inherently attenuated HIV …

CD4+ T-cell depletion in HIV infection: Are we closer to understanding the cause?

Z Grossman, M Meier-Schellersheim, AE Sousa… - Nature medicine, 2002 - nature.com
Is CD4+ cell depletion due to rapid elimination by HIV and failure of the immune system to
replace these cells at the required rate? Increasing evidence suggests that this is not the …

characteristics, determinants, and clinical relevance of CD4 T cell recovery to< 500 cells/µL in HIV type 1—infected individuals receiving potent antiretroviral therapy

GR Kaufmann, H Furrer, B Ledergerber… - Clinical infectious …, 2005 - academic.oup.com
Abstract Background. The CD4 T cell count recovery in human immunodeficiency virus type
1 (HIV-1)—infected individuals receiving potent antiretroviral therapy (ART) shows high …

Time trends in primary HIV-1 drug resistance among recently infected persons

RM Grant, FM Hecht, M Warmerdam, L Liu, T Liegler… - Jama, 2002 - jamanetwork.com
ContextTransmission of multiclass drug-resistant human immunodeficiency virus type 1 (HIV-
1) may increase with wider use of antiretroviral therapy. ObjectiveTo determine trends in …

HIV viral load monitoring in resource-limited regions: optional or necessary?

A Calmy, N Ford, B Hirschel… - Clinical infectious …, 2007 - academic.oup.com
Although it is a standard practice in high-income countries, determination of the human
immunodeficiency virus (HIV) load is not recommended in developing countries because of …