The evolution of SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused millions of
deaths and substantial morbidity worldwide. Intense scientific effort to understand the …
deaths and substantial morbidity worldwide. Intense scientific effort to understand the …
Why are RNA virus mutation rates so damn high?
S Duffy - PLoS biology, 2018 - journals.plos.org
Why are RNA virus mutation rates so damn high? | PLOS Biology Skip to main content
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Advertisement PLOS Biology Browse Current Issue Journal Archive Collections Find and …
Genomic epidemiology of superspreading events in Austria reveals mutational dynamics and transmission properties of SARS-CoV-2
A Popa, JW Genger, MD Nicholson, T Penz… - Science translational …, 2020 - science.org
Superspreading events shaped the coronavirus disease 2019 (COVID-19) pandemic, and
their rapid identification and containment are essential for disease control. Here, we provide …
their rapid identification and containment are essential for disease control. Here, we provide …
Analytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysis
Viral whole-genome sequencing (WGS) provides critical insight into the transmission and
evolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Long-read …
evolution of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Long-read …
An amplicon-based sequencing framework for accurately measuring intrahost virus diversity using PrimalSeq and iVar
How viruses evolve within hosts can dictate infection outcomes; however, reconstructing this
process is challenging. We evaluate our multiplexed amplicon approach, PrimalSeq, to …
process is challenging. We evaluate our multiplexed amplicon approach, PrimalSeq, to …
[HTML][HTML] Why does viral RNA sometimes persist after recovery from acute infections?
DE Griffin - PLoS biology, 2022 - journals.plos.org
DNA viruses often persist in the body of their host, becoming latent and recurring many
months or years later. By contrast, most RNA viruses cause acute infections that are cleared …
months or years later. By contrast, most RNA viruses cause acute infections that are cleared …
The enzymatic activity of the nsp14 exoribonuclease is critical for replication of MERS-CoV and SARS-CoV-2
NS Ogando, JC Zevenhoven-Dobbe… - Journal of …, 2020 - Am Soc Microbiol
Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing
machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3 …
machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3 …
Mechanisms of viral mutation
R Sanjuán, P Domingo-Calap - Cellular and molecular life sciences, 2016 - Springer
The remarkable capacity of some viruses to adapt to new hosts and environments is highly
dependent on their ability to generate de novo diversity in a short period of time. Rates of …
dependent on their ability to generate de novo diversity in a short period of time. Rates of …
The life cycle of non-polio enteroviruses and how to target it
J Baggen, HJ Thibaut, JRPM Strating… - Nature Reviews …, 2018 - nature.com
The genus Enterovirus (EV) of the family Picornaviridae includes poliovirus,
coxsackieviruses, echoviruses, numbered enteroviruses and rhinoviruses. These diverse …
coxsackieviruses, echoviruses, numbered enteroviruses and rhinoviruses. These diverse …
[HTML][HTML] Viral quasispecies
E Domingo, C Perales - PLoS genetics, 2019 - journals.plos.org
Viral quasispecies refers to a population structure that consists of extremely large numbers
of variant genomes, termed mutant spectra, mutant swarms or mutant clouds. Fueled by high …
of variant genomes, termed mutant spectra, mutant swarms or mutant clouds. Fueled by high …