[HTML][HTML] Machinery, regulation and pathophysiological implications of autophagosome maturation
YG Zhao, P Codogno, H Zhang - Nature Reviews Molecular Cell …, 2021 - nature.com
Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby
cytosolic materials are sequestered in a double-membrane autophagosome and …
cytosolic materials are sequestered in a double-membrane autophagosome and …
[HTML][HTML] Autophagy in inflammation, infection, and immunometabolism
V Deretic - Immunity, 2021 - cell.com
Autophagy is a quality-control, metabolic, and innate immunity process. Normative
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …
autophagy affects many cell types, including hematopoietic as well as non-hematopoietic …
[HTML][HTML] Coronavirus biology and replication: implications for SARS-CoV-2
P V'kovski, A Kratzel, S Steiner, H Stalder… - Nature Reviews …, 2021 - nature.com
The SARS-CoV-2 pandemic and its unprecedented global societal and economic disruptive
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …
impact has marked the third zoonotic introduction of a highly pathogenic coronavirus into the …
[HTML][HTML] Functions of ROS in macrophages and antimicrobial immunity
M Herb, M Schramm - Antioxidants, 2021 - mdpi.com
Reactive oxygen species (ROS) are a chemically defined group of reactive molecules
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …
derived from molecular oxygen. ROS are involved in a plethora of processes in cells in all …
[HTML][HTML] The natural history, pathobiology, and clinical manifestations of SARS-CoV-2 infections
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of
coronavirus disease 2019 (COVID-19). SARS-CoV-2, is a positive-sense single-stranded …
coronavirus disease 2019 (COVID-19). SARS-CoV-2, is a positive-sense single-stranded …
[HTML][HTML] SARS-CoV-2 non-structural protein 6 triggers NLRP3-dependent pyroptosis by targeting ATP6AP1
A recent mutation analysis suggested that Non-Structural Protein 6 (NSP6) of the Severe
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a key determinant of the viral …
Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a key determinant of the viral …
[HTML][HTML] ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation
G Miao, H Zhao, Y Li, M Ji, Y Chen, Y Shi, Y Bi… - Developmental cell, 2021 - cell.com
Autophagy acts as a cellular surveillance mechanism to combat invading pathogens.
Viruses have evolved various strategies to block autophagy and even subvert it for their …
Viruses have evolved various strategies to block autophagy and even subvert it for their …
[HTML][HTML] Targeting the endocytic pathway and autophagy process as a novel therapeutic strategy in COVID-19
N Yang, HM Shen - International journal of biological sciences, 2020 - ncbi.nlm.nih.gov
Coronaviruses (CoVs) are a group of enveloped, single-stranded positive genomic RNA
viruses and some of them are known to cause severe respiratory diseases in human …
viruses and some of them are known to cause severe respiratory diseases in human …
[HTML][HTML] Human coronavirus: host-pathogen interaction
TS Fung, DX Liu - Annual review of microbiology, 2019 - annualreviews.org
Human coronavirus (HCoV) infection causes respiratory diseases with mild to severe
outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly …
outcomes. In the last 15 years, we have witnessed the emergence of two zoonotic, highly …
[HTML][HTML] The SARS-CoV-2 protein ORF3a inhibits fusion of autophagosomes with lysosomes
Y Zhang, H Sun, R Pei, B Mao, Z Zhao, H Li, Y Lin, K Lu - Cell discovery, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the ongoing
coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to …
coronavirus disease 2019 pandemic. How SARS-CoV-2 regulates cellular responses to …