DNA degradation is critical to healthy organism development and survival. Two nuclease
families that play key roles in development and in disease are the Dnase1 and Dnase2 …

Detection of microbial nucleic acids by the innate immune system is mediated by numerous
intracellular nucleic acids sensors. Upon the detection of nucleic acids these sensors induce …

Caspase-activated DNase (CAD) is the most favorable candidate for chromatin degradation
during apoptosis. Ca 2+-dependent endonucleases are equally important in …

Ehrlichia chaffeensis, an obligatory intracellular rickettsial pathogen, enters and replicates in
monocytes/macrophages and several non-phagocytic cells. E. chaffeensis entry into …

The human genome contains four DNase1 and two DNase2 genes. The origin and
functional specialization of this repertoire are not fully understood. Here we use genomics …

Background Utilization of alternative initiation sites for protein translation directed by non-
AUG codons in mammalian mRNAs is observed with increasing frequency. Alternative …

DNase X is the first mammalian DNase to be isolated that is homologous to DNase I. In this
study, we have examined its function using a novel monoclonal antibody and showed it to …

Definition The deoxyribonuclease 1 (Dnase1) family is a key family of endonucleases that
degrades DNA. Loss of Dnase1 family function causes several diseases where the host's …

Deoxyribonuclease (DNase) is an enzyme that catalyzes the cleavage of phosphodiester
bonds in the main chain of DNA to degrade DNA. DNase serves a vital role in several …

Many nonsynonymous single-nucleotide polymorphisms (SNPs) in the human
deoxyribonuclease I-like 1 (DNase 1L1) gene, possibly implicated in the blocking of …