Recent trends in chemistry, structure, and various applications of 1-acyl-3-substituted thioureas: a detailed review
The interest in acyl thioureas has continually been escalating owing to their extensive
applications in diverse fields, such as synthetic precursors of new heterocycles …
applications in diverse fields, such as synthetic precursors of new heterocycles …
Alkaline phosphatase: a reliable endogenous partner for drug delivery and diagnostics
B Le‐Vinh, ZB Akkuş‐Dağdeviren… - Advanced …, 2022 - Wiley Online Library
Since the 1960s the membrane‐bound enzyme alkaline phosphatase (ALP) has been
utilized in drug delivery. As it cleaves phosphate substructures from drugs, auxiliary agents …
utilized in drug delivery. As it cleaves phosphate substructures from drugs, auxiliary agents …
Recent advances with alkaline phosphatase isoenzymes and their inhibitors
DM Zaher, MI El‐Gamal, HA Omar… - Archiv der …, 2020 - Wiley Online Library
Alkaline phosphatases are found in different living species and play crucial roles in various
significant functions, such as hydrolyzing a variable spectrum of phosphate‐containing …
significant functions, such as hydrolyzing a variable spectrum of phosphate‐containing …
Lactobacillus gallinarum-derived metabolites boost anti-PD1 efficacy in colorectal cancer by inhibiting regulatory T cells through modulating IDO1/Kyn/AHR axis
Objective Gut microbiota is a key player in dictating immunotherapy response. We aimed to
explore the immunomodulatory effect of probiotic Lactobacillus gallinarum and its role in …
explore the immunomodulatory effect of probiotic Lactobacillus gallinarum and its role in …
Current status of N-, O-, S-heterocycles as potential alkaline phosphatase inhibitors: a medicinal chemistry overview
Heterocycles are a class of compounds that have been found to be potent inhibitors of
alkaline phosphatase (AP), an enzyme that plays a critical role in various physiological …
alkaline phosphatase (AP), an enzyme that plays a critical role in various physiological …
2-Benzylidenebenzofuran-3 (2 H)-ones as a new class of alkaline phosphatase inhibitors: synthesis, SAR analysis, enzyme inhibitory kinetics and computational …
The excelling role of organic chemistry in the medicinal field continues to be one of the main
leads in the drug development process. Particularly, this industry requires organic chemists …
leads in the drug development process. Particularly, this industry requires organic chemists …
New acetylphenol-based acyl thioureas broaden the scope of drug candidates for urease inhibition: synthesis, in vitro screening and in silico analysis
Helicobacter pylori urease remains a validated drug target for the eradication of pervasive
chronic stomach infection that leads to severe human health diseases such as gastritis and …
chronic stomach infection that leads to severe human health diseases such as gastritis and …
Recent advances in urea-and thiourea-based metal complexes: biological, sensor, optical, and corroson inhibition studies
Ureas and thioureas, otherwise known as carbamides and thiocarbamides, respectively, are
rich sources of nitrogen. Urea has a wide range of applications in agriculture, the chemical …
rich sources of nitrogen. Urea has a wide range of applications in agriculture, the chemical …
Synthesis of benzamide derivatives with thiourea‐substituted benzenesulfonamides as carbonic anhydrase inhibitors
The novel compounds with the chemical structure of N‐({4‐[N′‐(substituted) sulfamoyl]
phenyl} carbamothioyl) benzamide (1a–g) and 4‐fluoro‐N‐({4‐[N′‐(substituted) sulfamoyl] …
phenyl} carbamothioyl) benzamide (1a–g) and 4‐fluoro‐N‐({4‐[N′‐(substituted) sulfamoyl] …
Exploring thiazole-linked thioureas using alkaline phosphatase assay, biochemical evaluation, computational analysis and structure–activity relationship (SAR) …
This study was carried out to identify the synthesis of a new group of thiazole-linked
thioureas with aromatic and aliphatic side chains (4a–k) using a one-pot three-component …
thioureas with aromatic and aliphatic side chains (4a–k) using a one-pot three-component …