The study of genes mutated in human disease often leads to new insights into biology as
well as disease mechanisms. One such gene is Wilms' tumour 1 (WT1), which plays multiple …

Simple Summary Immune checkpoint inhibitors (ICIs) have emerged as a very promising
therapeutic option for the treatment of many difficult-to-treat cancers and a number of clinical …

Genetic studies have identified recurrent somatic mutations in acute myeloid leukemia
(AML) patients, including in the Wilms' tumor 1 (WT1) gene. The molecular mechanisms by …

ABSTRACT WT1 has been reported to function as an oncogene and a tumor suppressor in
acute myeloid leukemia (AML). The molecular mechanisms have not yet been fully …

Renal cell carcinoma (RCC) is arguably the deadliest form of genitourinary malignancy and
is nowadays viewed as a heterogeneous series of cancers, with the same origin but …

WT1 disorder is characterized by congenital/infantile or childhood onset of steroid-resistant
nephrotic syndrome (SRNS), a progressive glomerulopathy that does not respond to …

Rubella vaccination induces widely variable immune responses in vaccine recipients. While
rubella vaccination is effective at inducing immunity to rubella infection in most subjects, up …

Bioinformatics analysis and identification of genes and pathways involved in patients with
Wilms tumor - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

Hypoxia-inducible factors (HIFs) play a key role in the adaptation to low oxygen by
interacting with hypoxia response elements (HREs) in the genome. Cellular levels of the HIF …

Renal cell carcinoma (RCC) remains incurable in advanced stages. Biomarkers have
proven to be quite useful in cancer therapeutics. Herein, we provide a comparative …