Elucidating the mechanisms of Temozolomide resistance in gliomas and the strategies to overcome the resistance.
Temozolomide (TMZ) is a first-choice alkylating agent inducted as a gold standard therapy
for glioblastoma multiforme (GBM) and astrocytoma. A majority of patients do not respond to …
for glioblastoma multiforme (GBM) and astrocytoma. A majority of patients do not respond to …
O6-Methylguanine-DNA Methyltransferase (MGMT): Challenges and New Opportunities in Glioma Chemotherapy
W Yu, L Zhang, Q Wei, A Shao - Frontiers in oncology, 2020 - frontiersin.org
Chemoresistance has been a significant problem affecting the efficacy of drugs targeting
tumors for decades. MGMT, known as O6-methylguanine-DNA methyltransferase, is a DNA …
tumors for decades. MGMT, known as O6-methylguanine-DNA methyltransferase, is a DNA …
MGMT testing—the challenges for biomarker-based glioma treatment
Many patients with malignant gliomas do not respond to alkylating agent chemotherapy.
Alkylator resistance of glioma cells is mainly mediated by the DNA repair enzyme O 6 …
Alkylator resistance of glioma cells is mainly mediated by the DNA repair enzyme O 6 …
Paediatric and adult glioblastoma: multiform (epi) genomic culprits emerge
We have extended our understanding of the molecular biology that underlies adult
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …
Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
EE Cameron, KE Bachman, S Myöhänen, JG Herman… - Nature …, 1999 - nature.com
Densely methylated DNA associates with transcriptionally repressive chromatin
characterized by the presence of underacetylated histones 1, 2. Recently, these two …
characterized by the presence of underacetylated histones 1, 2. Recently, these two …
Alterations in DNA methylation: a fundamental aspect of neoplasia
Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …
DNA methylation and somatic mutations converge on the cell cycle and define similar evolutionary histories in brain tumors
T Mazor, A Pankov, BE Johnson, C Hong, EG Hamilton… - Cancer cell, 2015 - cell.com
The evolutionary history of tumor cell populations can be reconstructed from patterns of
genetic alterations. In contrast to stable genetic events, epigenetic states are reversible and …
genetic alterations. In contrast to stable genetic events, epigenetic states are reversible and …
Association of MGMT promoter methylation status with survival outcomes in patients with high-risk glioma treated with radiotherapy and temozolomide: an analysis …
EH Bell, P Zhang, BJ Fisher, DR Macdonald… - JAMA …, 2018 - jamanetwork.com
Importance The initial report of NRG Oncology/Radiation Therapy Oncology Group (RTOG)
0424 demonstrated a 3-year overall survival benefit with the addition of temozolomide to …
0424 demonstrated a 3-year overall survival benefit with the addition of temozolomide to …
Methylation matters
JF Costello, C Plass - Journal of medical genetics, 2001 - jmg.bmj.com
DNA methylation is not just for basic scientists any more. There is a growing awareness in
the medical field that having the correct pattern of genomic methylation is essential for …
the medical field that having the correct pattern of genomic methylation is essential for …
Intratumoral heterogeneity of the epigenome
T Mazor, A Pankov, JS Song, JF Costello - Cancer cell, 2016 - cell.com
Investigation into intratumoral heterogeneity (ITH) of the epigenome is in a formative stage.
The patterns of tumor evolution inferred from epigenetic ITH and genetic ITH are remarkably …
The patterns of tumor evolution inferred from epigenetic ITH and genetic ITH are remarkably …