Mechanobiology emerges at the crossroads of medicine, biology, biophysics and
engineering and describes how the responses of proteins, cells, tissues and organs to …

Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery
drive cell division. Growing evidence indicates that this machinery operates in a distinct …

The low photostability of fluorescent proteins is a limiting factor in many applications of
fluorescence microscopy. Here we present StayGold, a green fluorescent protein (GFP) …

Despite the availabilty of imaging-based and mass-spectrometry-based methods for spatial
proteomics, a key challenge remains connecting images with single-cell-resolution protein …

Although Huntington's disease is a late-manifesting neurodegenerative disorder, both
mouse studies and neuroimaging studies of presymptomatic mutation carriers suggest that …

INTRODUCTION The chromosome breakage-fusion-bridge (BFB) cycle is a catastrophic
mutational process, common during tumorigenesis, that results in gene amplification and …

To understand the mechanism of acquired resistance to poly (ADP-ribose) polymerase
inhibitors (PARPi) olaparib, we induced the formation of polyploid giant cancer cells …

INTRODUCTION A complete view of human biology can only be achieved by studying the
molecular components of its smallest functional unit, the cell. Cells are internally organized …

The correct spatial distribution of proteins is vital for their function and often mis‐localization
or ectopic expression leads to diseases. For more than a decade, the Human Protein Atlas …

Ki67 staining is widely used as a proliferation indicator in the clinic, despite poor
understanding of this protein's function or dynamics. Here, we track Ki67 levels under …