Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a
cytokine involved in various biological phenomena including ontogeny, morphogenesis …

For the past 30 years, improvements in the survival of patients with osteosarcoma have been
mostly incremental. Despite evidence of genomic instability and a high frequency of …

Clinical outcomes and treatment modalities for osteosarcoma, the most common primary
cancer of bone, have changed very little over the past 30 years. The peak incidence of …

Wnt signaling executes an indispensable performance in osteoblast differentiation, bone
development, homeostasis, and remodeling. Wnt signals trigger the intracellular Wnt …

The bone is a complex connective tissue composed of many different cell types such as
osteoblasts, osteoclasts, chondrocytes, mesenchymal stem/progenitor cells, hematopoietic …

Abstract Background The Wnt/β-catenin pathway is closely associated with osteosarcoma
(OS) development and metastatic progression. We investigated the antitumor activity of …

Wnt molecules are a class of cysteine-rich secreted glycoproteins that participate in various
developmental events during embryogenesis and adult tissue homeostasis. Since its …

Osteosarcoma is the most common malignant bone tumor in children and adolescents.
Although pathologic characteristics of this disease are clear and well established, much …

Osteosarcoma (OS) is the most common primary bone malignancy diagnosed in children
and adolescents with a high propensity for local invasion and distant metastasis. Despite …

The Wnt signaling pathway regulates some of the crucial aspects of cellular processes. The
beta-catenin dependent Wnt signaling (Wnt/β-catenin) pathway controls the expression of …