Histone H2AX phosphorylation on a serine four residues from the carboxyl terminus
(producing γH2AX) is a sensitive marker for DNA double-strand breaks (DSBs). DSBs may …

Formation of γ-H2AX in response to DNA double stranded breaks (DSBs) provides the basis
for a sensitive assay of DNA damage in human biopsies. The review focuses on the …

One of the earliest cellular responses to DNA double strand breaks (DSBs) is the
phosphorylation of the core histone protein H2AX (termed γH2AX). Persistent γH2AX is the …

DNA double strand breaks (DSB) are the gravest form of DNA damage in eukaryotic cells.
Failure to detect DSB and activate appropriate DNA damage responses can cause genomic …

OBJECTIVE Regional differences among adipose depots in capacities for fatty acid storage,
susceptibility to hypoxia, and inflammation likely contribute to complications of obesity. We …

Tumor cells are often deficient in DNA damage response (DDR) pathways, and anticancer
therapies are commonly based on genotoxic treatments using radiation and/or drugs that …

For large scale exposures of the human population to ionising radiation, there is a need for
cost-effective high throughput assessment of radiation exposure levels from biological …

The past year has seen considerable developments in the use of the DNA double-strand
breaks (DSBs) to evaluate genome alterations in cells undergoing a variety of genotoxic …

Background—A better knowledge of patient x-ray dose and the associated radiation risk in
pediatric interventional cardiology is warranted in view of the extensive use of x-rays and the …

Purpose To determine the effect of the use of iodinated contrast agents on the formation of
DNA double-strand breaks during chest computed tomography (CT). Materials and Methods …