Structural and evolutionary insights point to allosteric regulation of TRP ion channels
Conspectus The familiar pungent taste of spicy food, the refreshing taste of mint, and many
other physiological phenomena are mediated by transient receptor potential (TRP) ion …
other physiological phenomena are mediated by transient receptor potential (TRP) ion …
[HTML][HTML] On the therapeutic targets and pharmacological treatments for pain relief following spinal cord injury: A mechanistic review
Spinal cord injury (SCI) is globally considered as one of the most debilitating disorders,
which interferes with daily activities and life of the affected patients. Despite many …
which interferes with daily activities and life of the affected patients. Despite many …
Nanomolar Pulse Dipolar EPR Spectroscopy in Proteins: CuII–CuII and Nitroxide–Nitroxide Cases
K Ackermann, JL Wort, BE Bode - The Journal of Physical …, 2021 - ACS Publications
The study of ever more complex biomolecular assemblies implicated in human health and
disease is facilitated by a suite of complementary biophysical methods. Pulse dipolar …
disease is facilitated by a suite of complementary biophysical methods. Pulse dipolar …
TRPV1 pore turret dictates distinct DkTx and capsaicin gating
Many neurotoxins inflict pain by targeting receptors expressed on nociceptors, such as the
polymodal cationic channel TRPV1. The tarantula double-knot toxin (DkTx) is a peptide with …
polymodal cationic channel TRPV1. The tarantula double-knot toxin (DkTx) is a peptide with …
Electrophysiological measurement of ion channels on plasma/organelle membranes using an on-chip lipid bilayer system
Ion channels are located in plasma membranes as well as on mitochondrial, lysosomal, and
endoplasmic reticulum membranes. They play a critical role in physiology and drug …
endoplasmic reticulum membranes. They play a critical role in physiology and drug …
Natural active ingredients and TRPV1 modulation: focus on key chemical moieties involved in ligand–target interaction
Diseases such as cancer, neurological pathologies and chronic pain represent currently
unmet needs. The existing pharmacotherapeutic options available for treating these …
unmet needs. The existing pharmacotherapeutic options available for treating these …
Venom peptide toxins targeting the outer pore region of transient receptor potential vanilloid 1 in pain: implications for analgesic drug development
The transient receptor potential vanilloid 1 (TRPV1) ion channel plays an important role in
the peripheral nociceptive pathway. TRPV1 is a polymodal receptor that can be activated by …
the peripheral nociceptive pathway. TRPV1 is a polymodal receptor that can be activated by …
A molecular perspective on identifying TRPV1 thermosensitive regions and disentangling polymodal activation
DD Luu, AM Owens, MD Mebrat, WD Van Horn - Temperature, 2023 - Taylor & Francis
ABSTRACT TRPV1 is a polymodal receptor ion channel that is best known to function as a
molecular thermometer. It is activated in diverse ways, including by heat, protons (low pH) …
molecular thermometer. It is activated in diverse ways, including by heat, protons (low pH) …
Perspective on the Effect of Membrane Mimetics on Dynamic Properties of Integral Membrane Proteins
ID Sahu, GA Lorigan - The Journal of Physical Chemistry B, 2023 - ACS Publications
Integral membrane proteins are embedded into cell membranes by spanning the width of
the lipid bilayer. They play an essential role in important biological functions for the survival …
the lipid bilayer. They play an essential role in important biological functions for the survival …
Functional expression of TRPV1 Ion Channel in the Canine Peripheral Blood mononuclear cells
JK Bujak, D Kosmala, K Majchrzak-Kuligowska… - International journal of …, 2021 - mdpi.com
TRPV1, known as a capsaicin receptor, is the best-described transient receptor potential
(TRP) ion channel. Recently, it was shown to be expressed by non-excitable cells such as …
(TRP) ion channel. Recently, it was shown to be expressed by non-excitable cells such as …