Cancer is a leading cause of death worldwide. In many cases, the treatment of the disease is
limited due to the metastasis of cells to distant locations of the body through the blood and …

The tumor microenvironment (TME) is an essential intrinsic portion of hepatocellular
carcinoma (HCC) for the regulation of its origination, development, invasion, and metastasis …

Research on matrix metalloproteinases (MMPs) and in particular on gelatinase B, alias MMP-
9, has grown exponentially in the decade 2003–2012. Structural details about flexibility of …

Triple-negative breast cancers (TNBC) are aggressive with no effective targeted therapies. A
combined database analysis identified 32 inflammation-related genes differentially …

Background Autotaxin (ATX) is a secreted enzyme that converts lysophosphatidylcholine to
lysophosphatidic acid (LPA). LPA stimulates cell proliferation and migration and promotes …

The hepatic stellate cells in the liver are stimulated sustainably by chronic injury of the
hepatocytes, activating myofibroblasts, which produce abundant collagen. Myofibroblasts …

This review summarizes recently published data on the mechanisms of tumor cell interaction
with the tumor microenvironment. Tumor stroma influences the processes of …

Metastasis is the main cause of cancer-associated mortality. During this complicated
process, some cancer cells, also called circulating tumor cells (CTCs), detach from primary …

Lysophosphatidic acid (LPA) is a ubiquitously present signalling molecule involved in
diverse cellular processes such as cell migration, proliferation and differentiation. LPA acts …

Lysophosphatidic acid (LPA) refers to a family of simple phospholipids that act as ligands for
G protein-coupled receptors. While LPA exerts effects throughout the body in normal …