Mycobacterium tuberculosis (M. tb), the causative agent of tuberculosis (TB), is the current
leading cause of death due to a single infectious organism. Although curable, the broad …

BCG turns 100 this year and while it might not be the perfect vaccine, it has certainly
contributed significantly towards eradication and prevention of spread of tuberculosis (TB) …

Mycobacterium tuberculosis represents a world-wide health risk and immunosuppression is
a particular problem in M. tuberculosis infections. Although macrophages are primarily …

The constituents of mycobacteria are an effective immune adjuvant, as observed with
complete Freund's adjuvant. In this study, we demonstrated that the cell wall skeleton of …

The ability of dendritic cells (DC) to initiate immune responses in naive T cells is dependent
upon a maturation process that allows the cells to develop their potent Ag-presenting …

With the mechanistic understanding of immune checkpoints and success in checkpoint
blockade using antibodies for the treatment of certain cancers, immunotherapy has become …

To induce effector immunity, dendritic cells (DCs) must differentiate into fully mature cells.
We show that, after human monocyte-derived DCs were infected with virulent …

Leukemia is the most commonly diagnosed childhood cancer, although its etiology is still
largely unknown. Growing evidence supports a role for infection in the etiology of acute …

Background The Mycobacterium bovis Bacille Calmette-Guérin (BCG) vaccine is given to>
120 million infants each year worldwide. Most studies investigating the immune response to …

Summary Exposure to Mycobacterium tuberculosis (Mtb) may lead to active or latent
tuberculosis, or clearance of Mtb, depending essentially on the quality of the host's immune …