For more than two decades, sepsis was defined as a microbial infection that produces fever
(or hypothermia), tachycardia, tachypnoea and blood leukocyte changes. Sepsis is now …

Ischemic disorders, such as myocardial infarction, stroke, and peripheral vascular disease,
are the most common causes of debilitating disease and death in westernized cultures. The …

Sepsis occurs when an infection exceeds local tissue containment and induces a series of
dysregulated physiologic responses that result in organ dysfunction. A subset of patients …

The complement system has been considered for a long time as a simple lytic cascade,
aimed to kill bacteria infecting the host organism. Nowadays, this vision has changed and it …

Sepsis, a condition caused by severe infections, affects more than 30 million people
worldwide every year and remains the leading cause of death in hospitals,. Moreover …

Although acute or chronic inflammation is a common component of many clinical disorders,
the underlying processes can be highly distinct. In recent years, the complement system has …

Sepsis is the leading cause of death in critically ill patients in the United States. Yet the
individual host response to septicemia is variable, depending on the patient's immune …

Sepsis is a serious medical condition characterized by dysregulated systemic inflammatory
responses followed by immunosuppression. To study the pathophysiology of sepsis, diverse …

Severe sepsis, defined as sepsis with acute organ dysfunction, is associated with high
morbidity and mortality rates. The development of novel therapies for sepsis is critically …

Inflammatory response leading to organ dysfunction and failure continues to be the major
problem after injury in many clinical conditions such as sepsis, severe burns, acute …