Macrophages as tools and targets in cancer therapy

A Mantovani, P Allavena, F Marchesi… - Nature Reviews Drug …, 2022 - nature.com
Tumour-associated macrophages are an essential component of the tumour
microenvironment and have a role in the orchestration of angiogenesis, extracellular matrix …

Clinical relevance of tumour-associated macrophages

MJ Pittet, O Michielin, D Migliorini - Nature reviews Clinical oncology, 2022 - nature.com
In the past decade, substantial advances have been made in understanding the biology of
tumour-associated macrophages (TAMs), and their clinical relevance is emerging. A …

Single-cell meta-analyses reveal responses of tumor-reactive CXCL13+ T cells to immune-checkpoint blockade

B Liu, Y Zhang, D Wang, X Hu, Z Zhang - Nature cancer, 2022 - nature.com
Immune-checkpoint blockade (ICB) therapies represent a paradigm shift in the treatment of
human cancers; however, it remains incompletely understood how tumor-reactive T cells …

Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy

AM Luoma, S Suo, Y Wang, L Gunasti, CBM Porter… - Cell, 2022 - cell.com
Neoadjuvant immune checkpoint blockade has shown promising clinical activity. Here, we
characterized early kinetics in tumor-infiltrating and circulating immune cells in oral cancer …

Improved prediction of immune checkpoint blockade efficacy across multiple cancer types

D Chowell, SK Yoo, C Valero, A Pastore… - Nature …, 2022 - nature.com
Only a fraction of patients with cancer respond to immune checkpoint blockade (ICB)
treatment, but current decision-making procedures have limited accuracy. In this study, we …

Multiregional single-cell dissection of tumor and immune cells reveals stable lock-and-key features in liver cancer

L Ma, S Heinrich, L Wang, FL Keggenhoff… - Nature …, 2022 - nature.com
Intratumor heterogeneity may result from the evolution of tumor cells and their continuous
interactions with the tumor microenvironment which collectively drives tumorigenesis …

Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response

S Liu, JB Iorgulescu, S Li, M Borji, IA Barrera-Lopez… - Immunity, 2022 - cell.com
T cells mediate antigen-specific immune responses to disease through the specificity and
diversity of their clonotypic T cell receptors (TCRs). Determining the spatial distributions of T …

Determinants of anti-PD-1 response and resistance in clear cell renal cell carcinoma

L Au, E Hatipoglu, MR de Massy, K Litchfield, G Beattie… - Cancer cell, 2021 - cell.com
ADAPTeR is a prospective, phase II study of nivolumab (anti-PD-1) in 15 treatment-naive
patients (115 multiregion tumor samples) with metastatic clear cell renal cell carcinoma …

[HTML][HTML] Mapping single-cell transcriptomes in the intra-tumoral and associated territories of kidney cancer

R Li, JR Ferdinand, KW Loudon, GS Bowyer, S Laidlaw… - Cancer Cell, 2022 - cell.com
Tumor behavior is intricately dependent on the oncogenic properties of cancer cells and
their multi-cellular interactions. To understand these dependencies within the wider …

Stem-like exhausted and memory CD8+ T cells in cancer

T Gebhardt, SL Park, IA Parish - Nature Reviews Cancer, 2023 - nature.com
T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …