Approximately half of all colorectal cancers show p53 (TP53) gene mutations, with higher
frequencies observed in distal colon and rectal tumors and lower frequencies in proximal …

We give an overview of current methods for the detection of point mutations as well as small
insertions and deletions in clinical diagnostics. For each method, the following …

Background Genetic disorders that predispose people to colorectal cancer include the
polyposis syndromes and hereditary nonpolyposis colorectal cancer. In contrast to the …

Purpose: We recently presented evidence for tumor site and gender-specificity in the
survival benefit from adjuvant chemotherapy in Stage III colorectal cancer (CRC). In the …

An account of familial aggregation in breast/ovarian cancer has become possible with the
identification of BRCA1 germ-line mutations. We evaluated, for 249 individuals registered …

Hirschsprung disease (HSCR) is a congenital disorder characterised by intestinal
obstruction due to an absence of intramural ganglia along variable lengths of the intestine …

Abstract Neurofibromatosis type 2 (NF2) is a monogenic dominantly inherited disease that
predisposes to the development of tumors of the nervous system, particularly meningiomas …

The influence of p53 mutations on the response to ionizing radiation and survival was
retrospectively evaluated in patients treated with preoperative radiotherapy for rectal …

Replication errors (RER) are frequently seen in both sporadic and hereditary forms of
colorectal cancer. In hereditary nonpolyposis colorectal cancer (HNPCC), RER is associated …

To study the role of ras, p53 genes and HPV virus (16 and 18) in the development of
prostate cancer, we analyzed tissue sections from 27 patients affected with carcinomas …