It is more than 50years since the lysosome was discovered. Since then its hydrolytic
machinery, including proteases and other hydrolases, has been fairly well identified and …

Proteolytic enzymes are crucial for a variety of biological processes in organisms ranging
from lower (virus, bacteria, and parasite) to the higher organisms (mammals). Proteases …

Proteases are important for multiple processes during malignant progression, including
tumor angiogenesis, invasion and metastasis. Recent evidence reveals that tumor …

Cathepsins were originally identified as proteases that act in the lysosome. Recent work has
uncovered nontraditional roles for cathepsins in the extracellular space as well as in the …

Lysosomal cysteine cathepsins are a family of proteases that are involved in a myriad of
cellular processes from proteolytic degradation in the lysosome to bone resorption. These …

Proteases enzymatically hydrolyze peptide bonds in substrate proteins, resulting in a
widespread, irreversible posttranslational modification of the protein's structure and …

Introduction 3. Discovery of the cystatin superfamily 4. Evolution and classification of the
cystatin superfamily 5. General properties of the cystatin superfamily 5.1. Type 1 cystatins …

Cysteine proteases are widespread in nature. Their implication in numerous vital processes
and pathologies make them highly attractive targets for drug design. The proper functioning …

Human cysteine cathepsins form a family of eleven proteases (B, C, F, H, K, L, O, S, V, W,
X/Z) that play important roles in a considerable number of biological and pathophysiological …

Cysteine peptidases (CPs) are phylogenetically ubiquitous enzymes that can be classified
into clans of evolutionarily independent proteins based on the structural organization of the …