RNA-binding proteins play a key role in the regulation of all aspects of RNA metabolism,
from the synthesis of RNA to its decay. Protein-RNA interactions have been thought to be …

Alternative splicing is an important mechanism for controlling gene expression. It allows
large proteomic complexity from a limited number of genes. An interplay of cis-acting …

In a previous proteomic study of the human spliceosome, we identified 42 spliceosome-
associated factors, including 19 novel ones. Using enhanced mass spectrometric tools and …

PROTEIN SEQUENCE MOTIFS ligands4, rendering it unlikely that components of the
general secretion or glycosylation machinery are Porcupine targets. Another candidate …

Transcription and pre-mRNA splicing are extremely complex multimolecular processes that
involve protein–DNA, protein–RNA, and protein–protein interactions. Splicing occurs in the …

ZO (zonula occludens) proteins are scaffolding proteins providing the structural basis for the
assembly of multiprotein complexes at the cytoplasmic surface of intercellular junctions. In …

A number of long noncoding RNA s (lnc RNA s) are induced in response to specific stresses
to construct membrane‐less nuclear bodies; however, their function remains poorly …

Abstract stella is a novel gene specifically expressed in primordial germ cells, oocytes,
preimplantation embryos, and pluripotent cells [1, 2]. It encodes a protein with a SAP-like …

Spinal muscular atrophy (SMA), a common motor neuron disease in humans, results from
loss of functional survival motor neuron (SMN1) alleles. A nearly identical copy of the gene …

Abstract t (1; 22) is the principal translocation of acute megakaryoblastic leukemias. Here we
show this chromosomal rearrangement to result in the fusion of two novel genes, RNA …