Genomic instability consists of a range of genetic alterations within the genome that
contributes to tumor heterogeneity and drug resistance. It is a well-established characteristic …

Background MicroRNAs (miRNAs) represent a novel class of single-stranded RNA
molecules of 18–22 nucleotides that serve as powerful tools in the regulation of gene …

Abstract Background MicroRNA-155-5p (miR-155-5p) has been reported to play an
oncogenic role in different human malignancies; however, its role in Wilms tumor (WT) …

Chronic Lymphocytic Leukemia (CLL) is the most common form of leukemia in adults, with a
highly variable clinical course. Improvement in the knowledge of the molecular pathways …

Autoimmunity and hematological malignancies are often concomitant in patients. A causal
bidirectional relationship exists between them. Loss of immunological tolerance with …

The scarcity of chondrocytes is a major challenge for cartilage tissue engineering.
Monolayer expansion is necessary to amplify the limited number of chondrocytes needed for …

In the past decade, novel targeted therapy approaches, such as BTK inhibitors and Bcl2
blockers, and innovative treatments that regulate the immune response against cancer cells …

Abstract Chronic Lymphocytic Leukemia (CLL) is the most common form of leukemia in
adults, with a highly variable clinical course. Improvement in the knowledge of the molecular …

Aneuploidy and overexpression of hsa-miR-155-5p (miR-155) characterize most solid and
hematological malignancies. We recently demonstrated that miR-155 sustains aneuploidy at …

Leukemia is an aberrant hyper-proliferation of immature blood cells that do not form solid
tumors. The transcriptomes of microRNAs (miRNAs) of leukemia have been intensively …