Cuproptosis was a copper-dependent and unique kind of cell death that was separate from
existing other forms of cell death. The last decade has witnessed a considerable increase in …

Higher eukaryotes' life is impossible without copper redox activity and, literally, every breath
we take biochemically demonstrates this. However, this dependence comes at a …

Copper is an essential trace metal element that significantly affects human physiology and
pathology by regulating various important biological processes, including mitochondrial …

In the past decade, evidence for the numerous roles of copper (Cu) in mammalian
physiology has grown exponentially. The discoveries of Cu involvement in cell signaling …

Cuproptosis, a recently identified form of cell death that differs from other forms, is induced
by the disruption of the binding of copper to mitochondrial respiratory acylation components …

Copper is a critical element for eukaryotic life involved in numerous cellular functions,
including redox balance, but is toxic in excess. Therefore, tight regulation of copper …

Transition metal ions, such as copper, are indispensable components in the biological
system. Copper ions which primarily exist in two major oxidation states Cu (I) and Cu (II) play …

Summary LAT1 (SLC7A5) is one of the most studied membrane transporters due to its
relevance to physiology in supplying essential amino acids to brain and fetus, and to …

Copper (Cu) is essential for all life forms; however, in excess, it becomes toxic. Toxic
properties of Cu are known to be utilized by host species against various pathogenic …

In addition to the essential structural and catalytic functions of zinc, evolution has adopted
synaptic zinc as a neuromodulator. In the brain, synaptic zinc is released primarily from …