Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment

RA McCutcheon, RSE Keefe, PK McGuire - Molecular psychiatry, 2023 - nature.com
Cognitive deficits are a core feature of schizophrenia, account for much of the impaired
functioning associated with the disorder and are not responsive to existing treatments. In this …

Adverse drug reactions in relation to clozapine plasma levels: a systematic review

M Skokou, EA Karavia, Z Drakou… - Pharmaceuticals, 2022 - mdpi.com
Clozapine is the gold standard for treatment-resistant schizophrenia. Serious and even life-
threatening adverse effects, mostly granulocytopenia, myocarditis, and constipation, are of …

The interplay between vitamin D, exposure of anticholinergic antipsychotics and cognition in schizophrenia

AJ Gaebler, M Finner-Prével, FP Sudar, FH Langer… - Biomedicines, 2022 - mdpi.com
Vitamin D deficiency is a frequent finding in schizophrenia and may contribute to
neurocognitive dysfunction, a core element of the disease. However, there is limited …

Effects of antipsychotic and anticholinergic medications on cognition in chronic patients with schizophrenia

C Haddad, P Salameh, H Sacre, JP Clément, B Calvet - BMC psychiatry, 2023 - Springer
Background Patients with psychosis frequently use a variety of psychotropic medicines,
many of which have anticholinergic effects that can impair cognition. Therefore, this study …

The effect of anticholinergic burden of psychiatric medications on major outcome domains of psychotic disorders: A 21-year prospective cohort study

V Peralta, EG de Jalón, L Moreno-Izco, D Peralta… - Schizophrenia …, 2024 - Elsevier
Background Most medications used to treat psychotic disorders possess anticholinergic
properties. This may result in a considerable anticholinergic burden (ACB), which may have …

Relapse of first-episode schizophrenia patients and neurocognitive impairment: The role of dopaminergic and anticholinergic burden

MJ Cuesta, A Ballesteros, AM Sánchez-Torres… - Schizophrenia …, 2022 - Elsevier
Background The prevention of relapse may be a key factor to diminish the cognitive
impairment of first-episode schizophrenia (FES) patients. We aimed to ascertain the effects …

[HTML][HTML] Effect of anticholinergic burden on brain activity during Working Memory and real-world functioning in patients with schizophrenia

P Selvaggi, L Fazio, VD Toro, A Mucci, P Rocca… - Schizophrenia …, 2023 - Elsevier
Cognitive impairment has been associated with poor real-world functioning in patients with
Schizophrenia. Previous studies have shown that pharmacological treatment with …

Comparative analysis of anticholinergic burden scales to explain iatrogenic cognitive impairment and self-reported side effects in the euthymic phase of bipolar …

N Vidal, E Brunet-Gouet, S Frileux, B Aouizerate… - European …, 2023 - Elsevier
Bipolar disorders (BD) are characterized by cognitive impairment during the euthymic
phase, to which treatments can contribute. The anticholinergic properties of medications, ie …

Comparative analysis of anticholinergic burden scales to explain iatrogenic cognitive impairment in schizophrenia: results from the multicenter FACE-SZ cohort

N Vidal, P Roux, M Urbach, C Belmonte… - Frontiers in …, 2024 - frontiersin.org
Aim The anticholinergic properties of medications are associated with poorer cognitive
performance in schizophrenia. Numerous scales have been developed to assess …

An Evidence-Based Update on Anticholinergic Use for Drug-Induced Movement Disorders

N Vanegas-Arroyave, SN Caroff, L Citrome, J Crasta… - CNS drugs, 2024 - Springer
Drug-induced movement disorders (DIMDs) are associated with use of dopamine receptor
blocking agents (DRBAs), including antipsychotics. The most common forms are drug …