The review presents metabolic properties of Ivermectin (IVM) as substrate and inhibitor of
human P450 (P450, CYP) enzymes and drug transporters. IVM is metabolized, both in vivo …

Finding new chemotherapeutic interventions to treat malaria through repurposing of time-
tested drugs and rigorous design of new drugs using tools of rational drug design remains …

Background The emergence and spread of multidrug-resistant Plasmodium falciparum in
the Greater Mekong Subregion (GMS) threatens global malaria elimination efforts. Mass …

Background Discovery and development of novel drugs that are capable of overcoming drug
resistance in tumor cells are urgently needed clinically. In this study, we sought to explore …

In the context of stalling progress against malaria, resistance of mosquitoes to insecticides,
and residual transmission, mass drug administration (MDA) of ivermectin, an endectocide …

Malaria is one of the most life-threatening infectious diseases and constitutes a major health
problem, especially in Africa. Although artemisinin combination therapies remain efficacious …

Mansonellosis is caused by three filarial parasite species from the genus Mansonella that
commonly produce chronic human microfilaraemias: M. ozzardi, M. perstans and M …

Background Malaria is the most common vector-borne disease transmitted to humans by
Anopheles mosquitoes. Endectocides and especially ivermectin will be available as a vector …

Background Treatment is the principle way to control and eliminate piroplasmosis. The
search for new chemotherapy against Babesia and Theileria has become increasingly …

Mass drug administration of ivermectin has been proposed as a possible malaria elimination
tool. Ivermectin exhibits a mosquito‐lethal effect well beyond its biological half‐life …