Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and
represents a high-grade neoplasm of skeletal myoblast-like cells. Decades of clinical and …

The regulation of oxidative stress is an important factor in both tumour development and
responses to anticancer therapies. Many signalling pathways that are linked to …

The forkhead box O (FoxO) transcription factor family is a key player in an evolutionary
conserved pathway downstream of insulin and insulin-like growth factor receptors. The …

The drug rapamycin has important uses in oncology, cardiology, and transplantation
medicine, but its clinically relevant molecular effects are not understood. When bound to …

This WHO classification covers tumors of soft tissue and bone including inherited tumor
syndromes. Each entity is extensively discussed with information on clinicopathological …

A wide range of human diseases, including cancer, has a striking age-dependent onset.
However, the molecular mechanisms that connect aging and cancer are just beginning to be …

Forkhead box O (FOXO) transcription factors are involved in multiple signaling pathways
and play critical roles in a number of physiological and pathological processes including …

The receptor tyrosine kinase Mer (gene name Mertk) acts in vascular endothelial cells (ECs)
to tighten the blood-brain barrier (BBB) subsequent to viral infection, but how this is …

Type 2 diabetes is characterized by the inability of insulin to suppress glucose production in
the liver and kidney. Insulin inhibits glucose production by indirect and direct mechanisms …

Mast cells and basophils are important effector cells in T helper 2 (TH2)-cell-dependent,
immunoglobulin-E-associated allergic disorders and immune responses to parasites. The …