Smart nanoparticles for cancer therapy
Smart nanoparticles, which can respond to biological cues or be guided by them, are
emerging as a promising drug delivery platform for precise cancer treatment. The field of …
emerging as a promising drug delivery platform for precise cancer treatment. The field of …
In vitro selection of aptamers and their applications
MC DeRosa, A Lin, P Mallikaratchy… - Nature Reviews …, 2023 - nature.com
The introduction of the in vitro evolution method known as SELEX (systematic evolution of
ligands by exponential enrichment) more than 30 years ago led to the conception of …
ligands by exponential enrichment) more than 30 years ago led to the conception of …
Capture-SELEX for aptamer selection: A short review
C Lyu, IM Khan, Z Wang - Talanta, 2021 - Elsevier
The emerging aptamer, developed through the systematic evolution of ligands by
exponential enrichment (SELEX) process, has revolutionized and facilitated the discoveries …
exponential enrichment (SELEX) process, has revolutionized and facilitated the discoveries …
Microfluidics integrated biosensors: A leading technology towards lab-on-a-chip and sensing applications
A biosensor can be defined as a compact analytical device or unit incorporating a biological
or biologically derived sensitive recognition element immobilized on a physicochemical …
or biologically derived sensitive recognition element immobilized on a physicochemical …
Dynamic DNA nanotechnology: toward functional nanoscale devices
Dynamic DNA nanotechnology involves the creation of nanoscale devices made of DNA
whose primary function arises from their ability to undergo controlled motion or …
whose primary function arises from their ability to undergo controlled motion or …
Current approaches in SELEX: An update to aptamer selection technology
M Darmostuk, S Rimpelova, H Gbelcova, T Ruml - Biotechnology advances, 2015 - Elsevier
Systematic evolution of ligands by exponential enrichment (SELEX) is a well-established
and efficient technology for the generation of oligonucleotides with a high target affinity …
and efficient technology for the generation of oligonucleotides with a high target affinity …
Challenges and opportunities for small molecule aptamer development
M McKeague, MC DeRosa - Journal of nucleic acids, 2012 - Wiley Online Library
Aptamers are single‐stranded oligonucleotides that bind to targets with high affinity and
selectivity. Their use as molecular recognition elements has emerged as a viable approach …
selectivity. Their use as molecular recognition elements has emerged as a viable approach …
Aptamer nanomedicine for cancer therapeutics: barriers and potential for translation
Aptamer nanomedicine, including therapeutic aptamers and aptamer nanocomplexes, is
beginning to fulfill its potential in both clinical trials and preclinical studies. Especially in …
beginning to fulfill its potential in both clinical trials and preclinical studies. Especially in …
Computational tools for aptamer identification and optimization
D Sun, M Sun, J Zhang, X Lin, Y Zhang, F Lin… - TrAC Trends in …, 2022 - Elsevier
Aptamers are single-stranded DNA or RNA oligonucleotides that can selectively bind to a
specific target. They are generally obtained by SELEX, but the procedure is challenging and …
specific target. They are generally obtained by SELEX, but the procedure is challenging and …
Analysis of in vitro aptamer selection parameters
Nucleic acid aptamers are novel molecular recognition tools that offer many advantages
compared to their antibody and peptide-based counterparts. However, challenges …
compared to their antibody and peptide-based counterparts. However, challenges …