Glioblastoma (GBM) is the most malignant brain tumor and accounts for most adult brain
tumors. Current available treatment options for GBM are multimodal, which include surgical …

Covering up to 2022 Gossypol is a polyphenolic compound isolated from cottonseed. There
are two optical enantiomers of gossypol,(−)-gossypol and (+)-gossypol. Gossypol exists as …

Polyamines are small organic polycations that are absolutely required for cell growth and
proliferation; yet the basis for this requirement is mostly unknown. Here, we combined a …

BACKGROUND & AIMS: Prolyl and asparaginyl hydroxylases are key oxygen-sensing
enzymes that confer hypoxic sensitivity to transcriptional regulatory pathways including the …

The natural polyamines putrescine, spermidine and spermine are in multiple ways involved
in cell growth and the maintenance of cell viability. In the course of the last 15 years more …

Phloroglucinol derivatives, dioxinodehydroeckol (1) and 1-(3′, 5′-dihydroxyphenoxy)-7-
(2′′, 4′′, 6-trihydroxyphenoxy)-2, 4, 9-trihydroxydibenzo-1, 4-dioxin (2), were isolated …

Activation of STAT3 (signal transducer and activator of transcription 3) plays a crucial role in
cell survival and proliferation. The aim of the present study was to clarify the role of STAT3 …

The BRAF V600E mutation is closely linked to tumorigenesis and malignant phenotype of
papillary thyroid cancer. Signaling pathways activated by BRAFV600E are still unclear …

Malignant (N-type) neuroblastoma continues to defy current chemotherapeutic regimens.
We tested the garlic compounds diallyl sulfide (DAS) and diallyl disulfide (DADS) for …

Intrauterine hypoxia (IUH) is a common intrauterine dysplasia that can cause programming
of the offspring cardiovascular system. In this study, we hypothesized that placental …