The life of U6 small nuclear RNA, from cradle to grave
AL Didychuk, SE Butcher, DA Brow - Rna, 2018 - rnajournal.cshlp.org
Removal of introns from precursor messenger RNA (pre-mRNA) and some noncoding
transcripts is an essential step in eukaryotic gene expression. In the nucleus, this process of …
transcripts is an essential step in eukaryotic gene expression. In the nucleus, this process of …
Characterizing RNA dynamics at atomic resolution using solution-state NMR spectroscopy
Many recently discovered noncoding RNAs do not fold into a single native conformation but
sample many different conformations along their free-energy landscape to carry out their …
sample many different conformations along their free-energy landscape to carry out their …
Visualizing transient low-populated structures of RNA
The visualization of RNA conformational changes has provided fundamental insights into
how regulatory RNAs carry out their biological functions. The RNA structural transitions that …
how regulatory RNAs carry out their biological functions. The RNA structural transitions that …
An excited state underlies gene regulation of a transcriptional riboswitch
B Zhao, SL Guffy, B Williams, Q Zhang - Nature chemical biology, 2017 - nature.com
Riboswitches control gene expression through ligand-dependent structural rearrangements
of the sensing aptamer domain. However, we found that the Bacillus cereus fluoride …
of the sensing aptamer domain. However, we found that the Bacillus cereus fluoride …
The conservation and function of RNA secondary structure in plants
LE Vandivier, SJ Anderson, SW Foley… - Annual review of …, 2016 - annualreviews.org
RNA transcripts fold into secondary structures via intricate patterns of base pairing. These
secondary structures impart catalytic, ligand binding, and scaffolding functions to a wide …
secondary structures impart catalytic, ligand binding, and scaffolding functions to a wide …
Characterizing micro-to-millisecond chemical exchange in nucleic acids using off-resonance R1ρ relaxation dispersion
This review describes off-resonance R 1ρ relaxation dispersion NMR methods for
characterizing microsecond-to-millisecond chemical exchange in uniformly 13 C/15 N …
characterizing microsecond-to-millisecond chemical exchange in uniformly 13 C/15 N …
A structural analysis of the group II intron active site and implications for the spliceosome
KS Keating, N Toor, PS Perlman, AM Pyle - Rna, 2010 - rnajournal.cshlp.org
Group II introns are self-splicing, mobile genetic elements that have fundamentally
influenced the organization of terrestrial genomes. These large ribozymes remain important …
influenced the organization of terrestrial genomes. These large ribozymes remain important …
RNA dynamics by NMR spectroscopy
M Marušič, J Schlagnitweit, K Petzold - ChemBioChem, 2019 - Wiley Online Library
An ever‐increasing number of functional RNAs require a mechanistic understanding. RNA
function relies on changes in its structure, so‐called dynamics. To reveal dynamic processes …
function relies on changes in its structure, so‐called dynamics. To reveal dynamic processes …
Characterizing protonation-coupled conformational ensembles in RNA via pH-differential mutational profiling with DMS Probing
EM Faison, A Nallathambi, Q Zhang - Journal of the American …, 2023 - ACS Publications
RNA molecules undergo conformational transitions in response to cellular and
environmental stimuli. Site-specific protonation, a fundamental chemical property, can alter …
environmental stimuli. Site-specific protonation, a fundamental chemical property, can alter …
Characterizing Slow Chemical Exchange in Nucleic Acids by Carbon CEST and Low Spin-Lock Field R1ρ NMR Spectroscopy
Quantitative characterization of dynamic exchange between various conformational states
provides essential insights into the molecular basis of many regulatory RNA functions. Here …
provides essential insights into the molecular basis of many regulatory RNA functions. Here …